| Autor: |
Hongzhe Shi, Chuanzhen Cao, Li Wen, Lianyu Zhang, Jin Zhang, Jianhui Ma, Jianzhong Shou, Changling Li |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMC urology. 22(1) |
| ISSN: |
1471-2490 |
| Popis: |
Background Several models and markers were developed and found to predict outcome of advanced renal cell carcinoma. This study aimed to evaluate the prognostic value of the ratio of maximum to minimum tumor diameter (ROD) in metastatic clear cell renal cell carcinoma (mccRCC). Methods Patients with mccRCC (n = 213) treated with sunitinib from January 2008 to December 2018 were identified. Cutoff value for ROD was determined using receiver operating characteristic. Patients with different ROD scores were grouped and evaluated. Survival outcomes were estimated by Kaplan–Meier method. Results The optimal ROD cutoff value of 1.34 was determined for progression free survival (PFS) and overall survival (OS). Patients in ROD ≥ 1.34 group had shorter PFS (9.6 versus 17.7 months, p Conclusion Primary tumor with higher ROD was an independently prognostic factor for both PFS and OS in patients with mccRCC who received targeted therapy. Higher ROD was also associated with high pT stage, high WHO/ISUP grade, sarcomatoid features, tumor necrosis, poor MSKCC and IMDC risk score. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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