The discovery of adamantyl-derived, inhaled, long acting beta(2)-adrenoreceptor agonists

Autor:	Christelle Perros-Huguet, Rob Webster, Mark E. Bunnage, Paul Alan Glossop, Rhys M. Jones, David Price, Simon John Mantell, Mike Trevethick, Russell Andrew Lewthwaite, Kim James, Alan Daniel Brown, Charlotte Alice Louise Lane
Rok vydání:	2007
Předmět:	Agonist medicine.medical_specialty medicine.drug_class Clinical Biochemistry Guinea Pigs Pharmaceutical Science Adamantane Biochemistry Pharmacokinetics Oral administration Internal medicine Drug Discovery Administration Inhalation medicine Animals Humans Molecular Biology Adrenergic beta-2 Receptor Agonists Chemistry Tissue Model Organic Chemistry Biological activity Adrenergic beta-Agonists Bioavailability Trachea Long acting Endocrinology Lung disease Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 18(4)
ISSN:	1464-3405
Popis:	The design and profile of a series of adamantyl-containing long acting β 2 -adrenoreceptor agonists are described. An optimal pharmacokinetic profile of low oral bioavailability was combined with a strong pharmacology profile when assessed using a guinea pig trachea tissue model. A focus was then placed on developing a robust synthetic route to ensure rapid delivery of material for clinical trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34542478cf335937d5e86586c76c0cc https://pubmed.ncbi.nlm.nih.gov/18226900 Zobrazit plný text záznamu Full Text from ScienceDirect