Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites
| Autor: | W. James Gauderman, Ivo S. Muskens, Adam J. de Smith, Lucy A. Godley, Qianxi Feng, Eric Nickels, Andrew D. Leavitt, Thomas M. Mack, Amy C. Yee, Joseph L. Wiemels, Charité Ricker |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Proband linked cancer registry Native Hawaiian or Other Pacific Islander Ethnic group global health California 0302 clinical medicine Risk Factors Neoplasms Epidemiology Ethnicity Medicine Biology (General) familial risk Child Minority Groups Cancer Hispanic paradox General Neuroscience Incidence latino americans General Medicine Hispanic or Latino Mental Health hispanic paradox 030220 oncology & carcinogenesis Child Preschool Pacific islanders Female epidemiology Research Article Human Adult medicine.medical_specialty Adolescent QH301-705.5 Concordance Science Black People early-onset cancer General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Young Adult Clinical Research Genetics Genetic predisposition Humans Genetic Predisposition to Disease human First-degree relatives Preschool General Immunology and Microbiology business.industry Prevention Infant Newborn Infant race/ethnicity Newborn medicine.disease Confidence interval 030104 developmental biology Epidemiology and Global Health Relative risk Biochemistry and Cell Biology business Demography |
| Zdroj: | eLife, Vol 10 (2021) eLife |
| Popis: | BackgroundThe role of race/ethnicity in genetic predisposition of early-onset cancers can be estimated by comparing family-based cancer concordance rates among ethnic groups.MethodsWe used linked California health registries to evaluate the relative cancer risks for first degree relatives of patients diagnosed between ages 0-26, and the relative risks of developing distinct second primary malignancies (SPMs). From 1989-2015, we identified 29,631 cancer patients and 62,863 healthy family members. We calculated the standardized incident ratios (SIRs) of early-onset primary cancers diagnosed in proband siblings and mothers, as well as SPMs detected among early-onset patients. Analyses were stratified by self-identified race/ethnicity.ResultsGiven probands with cancer, there were increased relative risks of any cancer for siblings and mothers [SIR=3.32;95% confidence interval (CI):2.85-3.85)] and of SPMs (SIR=7.27;95%CI:6.56-8.03). Higher relative risk of any cancer in siblings and mothers given a proband with solid cancer (PConclusionsThe data support a need for increased attention to the genetics of early-onset cancer predisposition and environmental factors in race/ethnic minority families in the US.FundingThis work was supported by the V Foundation for funding this work (Grant FP067172).Key MessagesWe identified 29 631 cancer patients and their 62 863 healthy family members in California from 1989 to 2015.The risk of early-onset cancer in siblings and mothers was elevated by having a proband with cancer in the same family.The relative risk of early-onset cancers given a proband with solid cancer was higher for Latinos and Blacks when compared to non-Latino Whites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|