Optimizing sodium balance in hemodialysis
| Autor: | A. Negro, I. Susa, Fidelio T, Iacono G, M. Della Casa, V Calitri, Deabate Mc, C. Amateis, C Licata, F. Cantone, A. Serra, Sancipriano Gp |
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| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_treatment
Sodium chemistry.chemical_element Diffusion Renal Dialysis medicine Humans Distribution Volume Aged Volume of distribution Chromatography Dialysis fluid Body Weight Membranes Artificial Hematology General Medicine Blood flow Models Theoretical Hemodialysis Solutions Volumetric flow rate chemistry Nephrology Female Hemodialysis Dialysis (biochemistry) |
| Zdroj: | Blood purification. 14(2) |
| ISSN: | 0253-5068 |
| Popis: | This paper develops and tests a mathematical model for Na+ kinetics applied to standard hemodialysis. The volume of distribution of exchangeable Na+, dialyzer surface area, blood and dialysis fluid flow rate, target weight loss, treatment duration and the Na+ diffusibility constant are taken into account. The model is used to compute the optimal hour by hour dialysis fluid Na+ concentration required to achieve the prescribed end-dialysis natremia and maintain a constant end-dialysis body Na+ pool, while providing a nearly uniform removal of Na+ over dialysis. The model was preliminarily tested on 10 consecutive dialyses in a single patient using a special dialyzer which generates a part of ultrafiltrate uncontaminated by dialysate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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