Treating Acute Leukemia During the COVID-19 Pandemic in an Environment With Limited Resources: A Multicenter Experience in Four Latin American Countries
| Autor: | Yu Ling Lee-Tsai, María Fernanda García-Leyva, Rosa González-Rivera, José Antonio de la Peña-Celaya, José Luis Álvarez-Vera, Elia Apodaca-Chávez, Karla Espinosa-Bautista, Juan Carlos Solís-Poblano, Eleazar Hernández-Ruiz, Cynthia Gómez-Cortés, Alejandra Córdoba-Ramírez, Álvaro Cabrera-García, Juan Rangel-Patiño, David Gómez-Almaguer, Estefanía Peña-López, Iván Murrieta-Álvarez, Ana Cooke-Tapia, Juan Manuel Pérez-Zúñiga, Mónica Tejeda-Romero, María Eugenia Espitia-Ríos, Daniel Rosales-López, Andrea I Milán-Salvatierra, Martha Alvarado-Ibarra, Jule Vasquez-Chávez, Andrés Gómez-De León, Fabián Amador-Medina, Guillermo J. Ruiz-Argüelles, Jorge Cruz-Rico, Nancy Delgado-López, Roberta Demichelis-Gómez, Luara L Arana-Luna, Carolina Balderas-Delgado |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult Male Cancer Research Latin Americans Coronavirus disease 2019 (COVID-19) Adolescent Panama Hematologic Malignancies Comorbidity Medical Oncology 03 medical and health sciences Young Adult 0302 clinical medicine Environmental health Pandemic Peru Global health Medicine Humans Prospective Studies Young adult Epidemics Mexico Aged Aged 80 and over Acute leukemia business.industry SARS-CoV-2 COVID-19 ORIGINAL REPORTS Middle Aged medicine.disease Guatemala 030104 developmental biology Oncology Leukemia Myeloid 030220 oncology & carcinogenesis Acute Disease Female business Limited resources |
| Zdroj: | JCO Global Oncology |
| ISSN: | 2687-8941 |
| Popis: | PURPOSE The COVID-19 pandemic is a colossal challenge for global health; nonetheless, specific subgroups face considerably higher risks for infection and mortality. Among patients with malignant diseases, those with hematologic neoplasms are at a higher risk for poor outcomes. The objective of this study was to register treatment modifications associated with the COVID-19 pandemic and their short-term consequences in Latin America. METHODS Multicenter, prospective, observational, cohort study including patients older than 14 years from 14 centers in four countries (Mexico, Peru, Guatemala, and Panama) who had a confirmed diagnosis of acute leukemia, and who were undergoing active treatment since the first COVID-19 case in each country until the cutoff on July 15, 2020. RESULTS We recruited 635 patients. Treatment modifications because of the COVID-19 pandemic were reported in 40.8% of cases. The main reason for such modifications was logistic issues (55.0%) and the most frequent modification was chemotherapy delay (42.0%). A total of 13.1% patients developed COVID-19 disease, with a mortality of 37.7%. Several factors were identified as independently associated with mortality, including a diagnosis of acute myeloid leukemia (odds ratio 2.38 [95% CI, 1.47 to 3.84]; P < .001), while the use of telemedicine was identified as a protective factor (odds ratio 0.36 [95% CI, 0.18 to 0.82]; P = .014). CONCLUSION These results highlight the collateral damage of COVID-19 in oncology patients. |
| Databáze: | OpenAIRE |
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