One-year impact of bariatric surgery on serum anti-Mullerian-hormone levels in severely obese women

Autor: René Valéro, F Maurice, Anne Dutour, Blandine Courbiere, Sophie Béliard, C. Vincentelli, Bruno Berthet, Bénédicte Gaborit, Olivier Emungania, Marie Maraninchi, Elise Lombard
Přispěvatelé: Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Nutrition, obésité et risque thrombotique (NORT), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'endocrinologie, diabète, maladies métaboliques [Hôpital de la Conception - APHM], Aix Marseille Université (AMU), Department of Nutrition, Metabolic Diseases, Endocrinology, CHU La Conception, Assistance Publique - Hôpitaux de Marseille (APHM), Service de Gynécologie et Obstétrique [Marseille], Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Centre recherche en CardioVasculaire et Nutrition (C2VN), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION ), Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université (AMU)-Avignon Université (AU)
Jazyk: angličtina
Rok vydání: 2018
Předmět:
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Body Mass Index
0302 clinical medicine
Weight loss
Medicine
Genetics (clinical)
030219 obstetrics & reproductive medicine
biology
Leptin
Obstetrics and Gynecology
Anti-Müllerian hormone
General Medicine
Middle Aged
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
Micronutrient
3. Good health
Obesity
Morbid
Reproductive Physiology and Disease
Child
Preschool
Female
medicine.symptom
Adult
Sleeve gastrectomy
medicine.medical_specialty
Adolescent
Gastric Bypass
030209 endocrinology & metabolism
[SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction
03 medical and health sciences
Young Adult
Gastrectomy
Weight Loss
Genetics
Humans
Obesity
Ovarian reserve
Bariatric surgery
Adiponectin
business.industry
Infant
Anti-Mullerian hormone
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology
medicine.disease
Surgery
Fertility
Reproductive Medicine
biology.protein
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Developmental Biology
Zdroj: Journal of Assisted Reproduction and Genetics
Journal of Assisted Reproduction and Genetics, Springer Verlag, 2018, 35 (7), pp.1317-1324. ⟨10.1007/s10815-018-1196-3⟩
Journal of Assisted Reproduction and Genetics, 2018, 35 (7), pp.1317-1324. ⟨10.1007/s10815-018-1196-3⟩
Journal of Assisted Reproduction and Genetics, Springer Verlag, In press, 35, pp.1317-1324. ⟨10.1007/s10815-018-1196-3⟩
ISSN: 1058-0468
1573-7330
Popis: INTRODUCTION: Although bariatric surgery seems to increase spontaneous fertility by improving ovulatory function in young women, its impact on ovarian reserve remains largely unknown. OBJECTIVE: To evaluate changes in serum anti-Mullerian hormone (AMH) levels in reproductive-age severely obese women after bariatric surgery (BS). METHODS: AMH levels were measured retrospectively in 39 women (mean age 34.6 ± 1.1 years, range 18–45) that underwent a sleeve gastrectomy or Roux-en-Y gastric bypass (RYGB) at baseline, and 6 and 12 months after BS. Metabolic and micronutrient status, including fasting plasma insulin and glucose, HOMA-IR, leptin, adiponectin, calcium, albumin, transthyretin, ferritin, vitamins (B9, B12, B1, A, E, D), zinc, and selenium, were assessed in all patients before and 1 year after BS. RESULTS: Of the patients, 79% had class-3 obesity. At 6 and 12 months, mean total weight losses (TWL) were 26 and 30%; mean excess weight losses (EWL) were 61.7 and 70.2%. Compared to baseline, AMH levels significantly decreased by 18% at 6 months, and 32% at 12 months post-operatively (p = 0.010 and p = 0.001, respectively). There was no correlation between AMH variation and changes in metabolic parameters or micronutrient levels. Remarkably, changes in AMH levels did not differ between sleeve and RYGB patients and were not correlated with EWL. CONCLUSION: This pilot study shows a drastic reduction in AMH levels at 1 year after BS in reproductive-age severely obese women, which was not related to weight loss: this suggests a negative impact of BS on ovarian reserve, at least in the short term. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10815-018-1196-3) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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