The number of cells used for immunotherapy of repeated spontaneous abortion influences pregnancy outcome
| Autor: | Jennifer A. Lata, F. Susan Cowchock, Barbara T. Hankinson, J. Bruce Smith |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Abortion Habitual medicine.medical_treatment Immunology Abortion Placebo Gastroenterology Peripheral blood mononuclear cell Subcutaneous injection Leukocyte Count Pregnancy Internal medicine medicine Immunology and Allergy Humans Gynecology business.industry Pregnancy Outcome Obstetrics and Gynecology Immunotherapy medicine.disease Flare reaction Reproductive Medicine Immunization Leukocytes Mononuclear Female business |
| Zdroj: | Journal of reproductive immunology. 22(3) |
| ISSN: | 0165-0378 |
| Popis: | One hundred and sixty-eight women were immunized on a single occasion with paternal mononuclear cells (MNC) for recurrent spontaneous abortion (RSA) and pregnancy outcomes were analysed with respect to the number of MNC given. The study was done in a prospective sequential fashion using all MNC recoverable from a unit of the spouse's blood and both patients and investigators were blinded as to the number of cells injected. Women receiving low and mid-range doses of MNC (58–305 × 10 6 and 308–567 × 10 6 , respectively) had a significantly higher pregnancy success rate (57%) than those receiving the high (568–2677 × 10 6 ) dose of MNC (41%). In 77 consecutive patients the diameter of the largest immediate skin flare reaction at the site of subcutaneous injection was recorded. No correlation was found between the skin flare response and the number of MNC injected. Our data suggest that a blinded trial of paternal MNC immunization comparing what appears to be optimum numbers of cells (100–550 million) to a low dose inoculum (e.g., 10 million), again noting the sizes of the skin flare reactions, might answer questions about efficacy and placebo effects of immunotherapy for RSA. |
| Databáze: | OpenAIRE |
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