The Mitochondrial Metabolic Checkpoint in Stem Cell Aging and Rejuvenation
| Autor: | Rika Ohkubo, Andrew Widjaja, Danica Chen, Wei-Chieh Mu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Protein Folding SIRT3 1.1 Normal biological development and functioning Clinical Sciences SIRT7 Biology NLR Family Stem cell aging SIRT2 Regenerative Medicine Article 03 medical and health sciences Mice 0302 clinical medicine Sirtuin 2 NLRP3 Underpinning research Sirtuin 3 NLR Family Pyrin Domain-Containing 3 Protein Animals Humans Rejuvenation Sirtuins Cellular Senescence Cell Proliferation Stem Cells Stem Cell Research Pyrin Domain-Containing 3 Protein Cell biology Mitochondria Tissue Degeneration Oxidative Stress 030104 developmental biology Phenotype Stem Cell Research - Nonembryonic - Non-Human Stem cell Gerontology 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Mech Ageing Dev |
| Popis: | Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged stem cells. Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the feasibility to target this checkpoint to reverse stem cell aging. We discuss the mechanisms by which mitochondrial stress leads to stem cell deterioration. We speculate the therapeutic potential of targeting the mitochondrial metabolic checkpoint for rejuvenating aged stem cells and improving aging tissue functions. |
| Databáze: | OpenAIRE |
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