HIV-2 infection in hospitalized patients in Bissau, Guinea-Bissau
| Autor: | Albino P, Sören Andersson, Anders Nauclér, P.A. Andreasson, Gunnel Biberfeld, Augusto Paolo Da Silva |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Tuberculosis Blood transfusion Adolescent medicine.medical_treatment Immunology Population HIV Infections HIV Antibodies Acquired immunodeficiency syndrome (AIDS) HIV Seroprevalence Internal medicine Epidemiology medicine Humans Immunology and Allergy Guinea-Bissau education Aged Acquired Immunodeficiency Syndrome education.field_of_study Deltaretrovirus Infections business.industry Public health virus diseases Middle Aged medicine.disease Case definition Hospitalization Infectious Diseases Case-Control Studies HIV-2 HIV-1 Female Viral disease business |
| Zdroj: | AIDS. 5:301-304 |
| ISSN: | 0269-9370 |
| DOI: | 10.1097/00002030-199103000-00009 |
| Popis: | During 11 months in 1989-1990, 1009 consecutive hospitalized adult patients admitted to the medical wards of the National Hospital in Bissau were interviewed, examined clinically, and tested for antibodies to HIV-1 and HIV-2. The prevalence of HIV-2 infection was 20.4% (206 out of 1009) and of HIV-2-associated AIDS 4.4% (44 out of 1009). HIV-2 infection was more frequent in women (25%, 110 out of 440) than in men (16.9%, 96 out of 569). HIV-1 infection was diagnosed in one patient only, and one patient (with AIDS) had reactivity to both HIV-1 and HIV-2. Among HIV-2-seropositive patients, AIDS was demonstrated in 21.3% and AIDS-related symptoms (not fulfilling the AIDS criteria) in 19.4%. The frequency of AIDS-associated symptoms was significantly higher in HIV-2-seropositive patients than in seronegative patients. The clinical profile of the HIV-2-associated AIDS cases was very similar to that described in HIV-1-associated AIDS cases in Africa. Seven out of 51 patients fulfilling the clinical criteria for AIDS were HIV-seronegative. The World Health Organization (WHO) clinical case definition for AIDS in Africa had a specificity of 99% and a positive predictive value of 86%. Tuberculosis was more common in HIV-2-seropositive patients (6.3%) than in HIV-2-seronegative patients (2.2%). A history of blood transfusion was a significant risk factor for HIV-2 infection. HIV-2 infection and AIDS are public health problems in Guinea-Bissau. |
| Databáze: | OpenAIRE |
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