INTRAVITREAL ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR FOR THE TREATMENT OF CHOROIDAL NEOVASCULARIZATION SECONDARY TO OCULAR HISTOPLASMOSIS
| Autor: | Nicholas E, Dudenhoefer, Carl W, Noble, Michael R, Petersen, Robert E, Foster, Christopher D, Riemann, Robert A, Sisk, Robert K, Hutchins, Daniel M, Miller |
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| Rok vydání: | 2022 |
| Předmět: |
Vascular Endothelial Growth Factor A
Photosensitizing Agents Visual Acuity Angiogenesis Inhibitors Endothelial Growth Factors General Medicine Antibodies Monoclonal Humanized Choroidal Neovascularization Ophthalmology Treatment Outcome Photochemotherapy Humans Prospective Studies Eye Infections Fungal Histoplasmosis Follow-Up Studies Retrospective Studies |
| Zdroj: | Retina. 42:1568-1573 |
| ISSN: | 0275-004X |
| Popis: | To assess the long-term efficacy of intravitreal antivascular endothelial growth factor injections (IVI), alone or in combination with verteporfin photodynamic therapy (IVI/PDT), for management of choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome (POHS).Retrospective, comparative, interventional case series analyzing 82 eyes in 74 patients treated with either IVI or IVI/PDT for presumed ocular histoplasmosis syndrome choroidal neovascularization from January 2006 to January 2021.The average logarithm of the minimum angle of resolution VA in year 5 was 0.40 (20/50) and 0.52 (20/67) for IVI versus IVI/PDT groups, respectively ( P = 0.33), and in year 10 was 0.53 (20/58) and 0.64 (20/86), respectively ( P = 0.50). The average number of annual injections over the first 5 years of follow-up was 3.3 versus 1.7 for IVI versus IVI/PDT groups, respectively ( P0.001), and over 10 years was 3.3 versus 1.6, respectively ( P0.001). Treatment-free interval of 5 years was reached by 39% versus 60% in IVI versus IVI/PDT groups, respectively ( P = 0.95).Our study found both IVI and IVI/PDT to be effective in long-term management of presumed ocular histoplasmosis syndrome choroidal neovascularization, with a fewer number of annual injections and longer treatment-free interval in the combination group. However, given the limitations of a retrospective study, a prospective randomized study is necessary to determine whether the addition of PDT significantly decreases treatment burden. |
| Databáze: | OpenAIRE |
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