Programmed Cell Death Protein Ligand 2 Is a Potential Biomarker That Predicts the Efficacy of Immunotherapy
| Autor: | Zheng Jin, Aoyun Wang, Han Chu, Qingzhu Jia, Bo Zhu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Medicine (General) medicine.medical_specialty Programmed cell death Article Subject medicine.medical_treatment Clinical Biochemistry Cell Interferon-gamma R5-920 Text mining Immune system Internal medicine Biomarkers Tumor Tumor Microenvironment Genetics Humans Medicine Immune Checkpoint Inhibitors Melanoma Molecular Biology Tumor microenvironment business.industry Biochemistry (medical) Computational Biology General Medicine Immunotherapy Programmed Cell Death 1 Ligand 2 Protein Treatment Outcome medicine.anatomical_structure Potential biomarkers business hormones hormone substitutes and hormone antagonists Research Article Protein ligand |
| Zdroj: | Disease Markers Disease Markers, Vol 2021 (2021) |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Immune checkpoint inhibitor (ICI) responses vary, and biomarkers for predicting responders are urgently needed. Growing evidence points to the association between programmed cell death protein ligand 2 (PDL2) and ICI benefits, while clinical evidences were lacking. Thus, we consolidated five public ICI-treated cohorts to investigate the association between PDL2 expression and ICI treatment prognosis. Immune cell signatures and IFN-γ signatures are investigated in The Cancer Genome Atlas (TCGA) dataset and later in ICI-treated cohorts to explore the association between PDL2 and antitumor immunity in the tumor microenvironment (TME). We found that immune cell signatures and IFN-γ signatures were enriched in the PDL2-high group in TCGA pooled cohorts and most cancers. Consistently, in ICI-treated cohorts, patients with high PDL2 expression experienced longer overall survival time (OS) and were more likely responsive to ICIs than patients with low PDL2 expression. Immune cell scores of the high PDL2 expression patients were significantly higher ( P < 0.05 ) than those of the low PDL2 expression patients in ICI-treated cohorts. In conclusion, our findings suggest that PDL2 is a potential predictive biomarker for ICIs. |
| Databáze: | OpenAIRE |
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