Effect of Memantine on Cue-Induced Alcohol Craving in Recovering Alcohol-Dependent Patients
| Autor: | Olga N Neznanova, Anton Bespalov, Ismene L. Petrakis, T. Y. Didenko, Ralitza Gueorguieva, Dimitry V. Masalov, Edwin Zvartau, Burakov Am, John H. Krystal, Marina Tsoy, Evgeny Krupitsky, T. Y. Slavina, Brian Pittman, Romanova Tn, Alexander A. Grinenko |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Alcohol Craving Pharmacology Verbal learning Placebo chemistry.chemical_compound Cognition Double-Blind Method Memantine Humans Medicine Ethanol Dose-Response Relationship Drug business.industry Antagonist Verbal Learning Behavior Addictive Hospitalization Alcoholism Psychiatry and Mental health chemistry Anesthesia NMDA receptor Cues medicine.symptom business Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | American Journal of Psychiatry. 164:519-523 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | Ethanol blocks N-methyl-d-aspartic acid (NMDA) glutamate receptors. Increased NMDA receptor function may contribute to motivational disturbances that contribute to alcoholism. The authors assessed whether the NMDA receptor antagonist memantine reduces cue-induced alcohol craving and produces ethanol-like subjective effects.Thirty-eight alcohol-dependent inpatients participated in three daylong testing sessions in a randomized order under double-blind conditions. On each test day, subjects received 20 mg of memantine, 40 mg of memantine, or placebo, and subjective responses to treatment were assessed. The level of alcohol craving was assessed before and after exposure to an alcohol cue.Memantine did not stimulate alcohol craving before exposure to an alcohol cue, and it attenuated alcohol cue-induced craving in a dose-related fashion. It produced dose-related ethanol-like effects without adverse cognitive or behavioral effects.These data support further exploration of whether well-tolerated NMDA receptor antagonists might have a role in the treatment of alcoholism. |
| Databáze: | OpenAIRE |
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