Erythrocyte Pyridoxine Kinase Levels in Patients with Sideroblastic Anemia
| Autor: | Ram K. Chillar, Cage S. Johnson, Ernest Beutler, Katherine Sonne |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Erythrocytes Black People White People Cofactor chemistry.chemical_compound Sideroblastic anemia Hexokinase Internal medicine medicine Humans In patient Aspartate Aminotransferases Pyridoxal phosphate Pyridoxal chemistry.chemical_classification biology business.industry Phosphotransferases General Medicine medicine.disease Pyridoxal kinase Anemia Sideroblastic Alcoholism Endocrinology Enzyme chemistry Biochemistry Pyridoxal Phosphate biology.protein Vitamer business Alcoholic Intoxication |
| Zdroj: | New England Journal of Medicine. 295:881-883 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm197610142951608 |
| Popis: | IT has been suggested that a substantial number of patients with either idiopathic acquired or alcoholic sideroblastic anemia lack the enzyme, pyridoxine kinase, in their red blood cells.1 , 2 Therefore, such patients were thought to be unable to convert the naturally occurring vitamer of vitamin B6, pyridoxal, to its active coenzyme form, pyridoxal phosphate, which is needed for heme synthesis. Administration of pyridoxal phosphate to such patients was claimed to improve their anemia.3 We have now reinvestigated the putative existence of pyridoxine kinase deficiency in alcoholic and nonalcoholic patients with sideroblastic anemia, using a recently developed, improved method for . . . |
| Databáze: | OpenAIRE |
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