Patterns of recurrence following definitive chemoradiation for patients with proximal esophageal cancer

Autor: Tom Rozema, Francine E.M. Voncken, Stefan A W Bouwense, L. Valkenburg-van Iersel, Vivianne C. G. Tjan-Heijnen, Paul M. Jeene, G.J. Blom, J.A. Bogers, Nicolien Kasperts, Pètra M. Braam, M.A. de Jong, Frank J. P. Hoebers, S. M. E. Geurts, Christina T. Muijs, J. de Vos-Geelen, G.A.P. Nieuwenhuijzen
Přispěvatelé: Damage and Repair in Cancer Development and Cancer Treatment (DARE), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), MUMC+: MA Heelkunde (9), Radiotherapie
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Time Factors
Esophageal Neoplasms
SURGERY
IMPACT
Kaplan-Meier Estimate
Gastroenterology
THERAPY
Carboplatin
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
Upper thoracic
Cumulative incidence
Relapse
Complete response
Netherlands
Aged
80 and over
General Medicine
Chemoradiotherapy
Middle Aged
Esophageal cancer
CHEMOTHERAPY
Progression-Free Survival
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Cervical
Esophageal Squamous Cell Carcinoma
SQUAMOUS-CELL CARCINOMA
After treatment
RADIOTHERAPY
Adult
medicine.medical_specialty
Paclitaxel
Antineoplastic Agents
CONCURRENT CHEMORADIATION
Disease-Free Survival
03 medical and health sciences
CISPLATIN
Clinical complete response
Esophagus
Internal medicine
medicine
Humans
Aged
Retrospective Studies
Salvage Therapy
business.industry
Retrospective cohort study
medicine.disease
Esophagectomy
Squamous cell cancer
Neoplasm Recurrence
Local
business
Zdroj: EJSO, 47(8), 2016-2022. ELSEVIER SCI LTD
European Journal of Surgical Oncology, 47, 8, pp. 2016-2022
European Journal of Surgical Oncology, 47, 2016-2022
European Journal of Surgical Oncology, 47(8), 2016-2022. ELSEVIER SCI LTD
ISSN: 1532-2157
0748-7983
2016-2022
Popis: Introduction: The aim of this retrospective study was to determine the patterns of recurrence and overall survival (OS) in patients achieving clinical complete response after treatment with definitive chemoradiation (CRT) for proximal esophageal cancer.Materials and methods: Patients with proximal esophageal cancer treated with CRT between 2004 and 2014 in 11 centers in the Netherlands were included. OS and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Cumulative incidence of first recurrence (locoregional or distant) and locoregional recurrence (LRR) were assessed using competing risk analyses.Results: In 197 of the 200 identified patients, response was evaluated, 133 (68%) showed a complete response. In complete responders, median OS, three-year OS, and PFS were 45.0 months (95% CI 34.8-61.5 months), 58% (95% CI 48-66), and 49% (95% CI 40-57), respectively. Three- and five-year risk of recurrence were respectively 40% (95% CI 31-48), and 45% (95% CI 36-54). Three- and five-year risk of LRR were 26% (95% CI 19-33), and 30% (95% CI 22-38). Eight of 32 patients with an isolated LRR underwent salvage surgery, with a median OS of 32.0 months (95% CI 6.8-not reached).Conclusion: In patients with a complete response after definitive CRT for proximal esophageal cancer, most recurrences were locoregional and developed within the first three years after CRT. These findings suggest to shorten locoregional follow-up from five to three years. (C) 2021 The Authors. Published by Elsevier Ltd.
Databáze: OpenAIRE
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