In vitro activity of iclaprim and comparator agents against Listeria monocytogenes clinical isolates from 2012 to 2018
| Autor: | Michael D. Huband, Leonard R. Duncan, Robert K. Flamm, Paul R. Rhomberg, David B. Huang, Yahse K. Edah |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Susceptibility testing 030106 microbiology Immunology Microbial Sensitivity Tests Bloodstream infection medicine.disease_cause Microbiology 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine In vitro Listeria monocytogenes medicine Humans Iclaprim Immunology and Allergy 030212 general & internal medicine business.industry bacterial infections and mycoses Trimethoprim QR1-502 Dihydrofolate reductase inhibitor Anti-Bacterial Agents Europe Latin America Pyrimidines Mic values business Blood stream medicine.drug |
| Zdroj: | Journal of Global Antimicrobial Resistance, Vol 25, Iss, Pp 14-17 (2021) |
| ISSN: | 2213-7165 |
| DOI: | 10.1016/j.jgar.2021.02.015 |
| Popis: | Objective This study examined the in vitro activity of iclaprim and comparators against 40 Listeria monocytogenes clinical isolates mostly (95%) from patients with bloodstream infections (BSI) from the United States, Australia/New Zealand, Latin America, and Europe collected between 2012-2018 were tested. Methods Susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Minimum inhibitory concentration (MIC) interpretations were based on CLSI criteria. Results The iclaprim MIC90 value for all L. monocytogenes was 0.015 µg/ml. The MIC50/90 values for iclaprim were 4-fold lower than trimethoprim, the only FDA approved dihydrofolate reductase inhibitor, against all L. monocytogenes. Conclusions Iclaprim demonstrated lower MIC values than trimethoprim against a collection (2012-2018) of L. monocytogenes clinical isolates mostly from patients with blood stream infections from the United States, Australia/New Zealand, Latin America, and Europe. |
| Databáze: | OpenAIRE |
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