Identification of point mutations in the envelope gene of Moloney murine leukemia virus TB temperature-sensitive paralytogenic mutant ts1: molecular determinants for neurovirulence
| Autor: | P K Wong, R Jerzy, P F Szurek, P H Yuen |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
viruses
DNA Mutational Analysis Immunology Mutant Biology Microbiology Structure-Activity Relationship chemistry.chemical_compound Viral Envelope Proteins Virology Moloney Murine Leukemia Virus TB Amino Acid Sequence Gene Peptide sequence chemistry.chemical_classification Base Sequence Point mutation Temperature Phenotype Molecular biology Amino acid chemistry Insect Science Moloney murine leukemia virus Nervous System Diseases DNA Research Article |
| Zdroj: | Journal of Virology. 62:357-360 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, induces hind-limb paralysis in mice. The DNA of both the ts1 and Moloney murine leukemia virus TB env genes has been sequenced, and the encoded amino acid sequences have been deduced from the DNA sequences. Four amino acids in the ts1 envelope protein have been identified which may be responsible for the ts1 phenotype, which includes temperature sensitivity, nonprocessing of Pr80env, and neurovirulence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|