Limonin Derivatives: Synthesis Using Methodology in Solution and Heterogeneous Medium and Evaluation of the Antimicrobial Activity
| Autor: | Ademir F. Morel, Ubiratan F. da Silva, Vinicius Ilha, Eveline W. dos Santos, Alexandre T. Neto, Robert A. Burrow, Marco A. Mostardeiro, Fabio A. Duarte, Tanize S. Fernandes, Luciana de Carvalho Tavares, Erico M.M. Flores |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of the Brazilian Chemical Society, Volume: 27, Issue: 1, Pages: 161-178, Published: JAN 2016 Journal of the Brazilian Chemical Society v.27 n.1 2016 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| Popis: | We herein described the preparation of a novel series of limonin derivatives (modification in A-ring), which was synthesized efficiently using methodology in solution as well as in heterogeneous medium (K-10). In addition, we obtained derivatives by inserting the 1,2,3-triazole nucleus via click reaction and also prepared derivatives from reactions with limonin-7-oxime. All compounds were submitted to investigation of the antimicrobial activity against a collection of microorganisms. The results of the antimicrobial activity, in general, demonstrated that a relevant number of synthetic derivatives presented higher activity than the natural product. |
| Databáze: | OpenAIRE |
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