Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway
| Autor: | Wynn Legon, Jamu K. Alford, Hongsun Guo, Hubert H. Lim, Cory D. Gloeckner, Mark Hamilton, Tianqi Li, Sarah J. Offutt, Yohan Kim |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Deep brain stimulation Auditory Pathways medicine.medical_treatment Guinea Pigs Stimulation Somatosensory system Brain mapping 03 medical and health sciences 0302 clinical medicine medicine Auditory system Animals Neurostimulation Cochlear Nerve Auditory Cortex Cerebral Cortex Neurons Brain Mapping business.industry General Neuroscience Brain Neuromodulation (medicine) Cochlea Electrophysiological Phenomena Electrophysiology 030104 developmental biology medicine.anatomical_structure Ultrasonic Waves business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 98(5) |
| ISSN: | 1097-4199 |
| Popis: | Ultrasound (US) can noninvasively activate intact brain circuits, making it a promising neuromodulation technique. However, little is known about the underlying mechanism. Here, we apply transcranial US and perform brain mapping studies in guinea pigs using extracellular electrophysiology. We find that US elicits extensive activation across cortical and subcortical brain regions. However, transection of the auditory nerves or removal of cochlear fluids eliminates the US-induced activity, revealing an indirect auditory mechanism for US neural activation. Our findings indicate that US activates the ascending auditory system through a cochlear pathway, which can activate other non-auditory regions through cross-modal projections. This cochlear pathway mechanism challenges the idea that US can directly activate neurons in the intact brain, suggesting that future US stimulation studies will need to control for this effect to reach reliable conclusions. |
| Databáze: | OpenAIRE |
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