An exploration of patient-reported symptoms in systemic lupus erythematosus and the relationship to health-related quality of life
| Autor: | E. Welin Henriksson, Elisabet Svenungsson, C Moberg, Iva Gunnarsson, Susanne Pettersson, Malin Lövgren, Lars E. Eriksson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cross-sectional study Health Status Immunology MEDLINE Alternative medicine Nursing Anxiety Severity of Illness Index Diagnostic Self Evaluation Quality of life (healthcare) Rheumatology immune system diseases Surveys and Questionnaires Severity of illness medicine Immunology and Allergy Humans Lupus Erythematosus Systemic skin and connective tissue diseases Intensive care medicine Fatigue Aged Aged 80 and over Lupus erythematosus business.industry Depression Omvårdnad General Medicine Middle Aged medicine.disease Health Surveys Cross-Sectional Studies Physical therapy Quality of Life Female medicine.symptom business RC |
| ISSN: | 0300-9742 |
| Popis: | Objective: The aim of this study was to explore the most distressing symptoms of systemic lupus erythematosus (SLE) and determine how these relate to health-related quality of life (HRQoL), anxiety/depression, patient demographics, and disease characteristics (duration, activity, organ damage). Methods: In a cross-sectional study, patients with SLE (n = 324, age 18-84 years) gave written responses regarding which SLE-related symptoms they experienced as most difficult. Their responses were categorized. Within each category, patients reporting a specific symptom were compared with non-reporters and analysed for patient demographics, disease duration, and results from the following questionnaires: the Medical Outcomes Study 36-item Short Form Health Survey (SF-36), the Hospital Anxiety and Depression Scale (HADS), the Systemic Lupus Activity Measure (SLAM), the SLE Disease Activity Index (SLEDAI), and the Systemic Lupus International Collaboration Clinics/American College of Rheumatology (SLICC/ACR) damage index. Results: Twenty-three symptom categories were identified. Fatigue (51%), pain (50%), and musculoskeletal distress (46%) were most frequently reported. Compared with non-reporters, only patients reporting fatigue showed a statistically significant impact on both mental and physical components of HRQoL. Patients with no present symptoms (10%) had higher HRQoL (p < 0.001) and lower levels of depression (p < 0.001), anxiety (p < 0.01), and disease activity (SLAM) (p < 0.001). Conclusion: Fatigue, pain, or musculoskeletal distress dominated the reported symptoms in approximately half of the patients. Only patients reporting fatigue scored lower on both mental and physical aspects of HRQoL. Our results emphasize the need for further support and interventions to ease the symptom load and improve HRQoL in patients with SLE. Our findings further indicate that this need is particularly urgent for patients with symptoms of pain or fatigue. |
| Databáze: | OpenAIRE |
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