Fetuin-A levels in hyperthyroidism
| Autor: | Ozlem Gursoy Calan, Baris Onder Pamuk, Tugba Topcuoglu, Derun Taner Ertugrul, Oktay Bilgir, Gülseren Pamuk, Hamiyet Yilmaz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty endocrine system endocrine system diseases alpha-2-HS-Glycoprotein medicine.medical_treatment Thyrotropin Enzyme-Linked Immunosorbent Assay Thyroid Function Tests Thyroid function tests Hyperthyroidism Insulin resistance Internal medicine medicine Animals Humans lcsh:R5-920 medicine.diagnostic_test business.industry Insulin General Medicine Fasting Middle Aged Clinical Science medicine.disease Fetuin Fetuin-A Arterial calcification Endocrinology Basal (medicine) Female Insulin Resistance business lcsh:Medicine (General) alpha-2-HS-glycoprotein Homeostasis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinics; v. 68 n. 3 (2013); 379-383 Clinics; Vol. 68 Núm. 3 (2013); 379-383 Clinics; Vol. 68 No. 3 (2013); 379-383 Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 68, Issue: 3, Pages: 379-383, Published: 2013 Clinics, Vol 68, Iss 3, Pp 379-383 (2013) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: Fetuin-A is a protein secreted from the liver that inhibits arterial calcification deposition and can contribute to insulin resistance. Hyperthyroidism is also associated with insulin resistance. It is not known whether hyperthyroidism has an effect on fetuin-A levels. METHODS: We measured fetuin-A levels and homeostasis model of assessment-insulin resistance before hyperthyroidism treatment was initiated and after euthyroidism was achieved. A total of 42 patients diagnosed with hyperthyroidism were enrolled in this study. Fetuin-A, insulin, high-sensitivity C-reactive protein, fasting blood glucose, free T3 (fT3), free T4 (fT4), and thyrotropin were measured before and after euthyroidism was established. RESULTS: Basal fasting blood glucose, high-sensitivity C-reactive protein, insulin, c-peptide, homeostasis model of assessment-insulin resistance, fT3, fT4 and fetuin-A levels were significantly decreased after euthyroidism was achieved (Table 1). Basal fasting blood glucose (r:0.407, p:0.008), high-sensitivity C-reactive protein (r:0.523, p |
| Databáze: | OpenAIRE |
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