Association between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients
| Autor: | Sergej Nadalin, Sanja Dević Pavlić, Vjekoslav Peitl, Dalibor Karlović, Lena Zatković, Smiljana Ristić, Alena Buretić-Tomljanović, Hrvoje Jakovac |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Angiotensins Genotype BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Immunology Peptidyl-Dipeptidase A Catalysis angiotensin‐converting enzyme (ACE) polymorphism Inorganic Chemistry BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Psihijatrija BIOMEDICINE AND HEALTHCARE. Basic Medical Sciences. Human Genetics Genomics and Proteomics Humans Physical and Theoretical Chemistry Molecular Biology Spectroscopy Metabolic Syndrome psychiatry_mental_health_studies Organic Chemistry treatment response General Medicine BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Psychiatry Lipids antipsychotic medication Computer Science Applications angiotensin-converting enzyme (ACE) insertion/deletion Glucose Psychotic Disorders BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Imunologija Female BIOMEDICINA I ZDRAVSTVO. Temeljne medicinske znanosti. Genetika genomika i proteomika čovjeka Antipsychotic Agents |
| Zdroj: | International Journal of Molecular Sciences Volume 23 Issue 20 International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12180 |
| ISSN: | 1422-0067 |
| Popis: | We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients’ Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naïve first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis. The ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology only (p < 0.05). Compared to ACE-II homozygous males, ACE-DD homozygous and ACE-ID heterozygous males manifested significantly greater decreases in PANSS positive score, PANSS excitement factor, and PANSS cognitive factor. ACE-DD homozygous females manifested higher decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females. The polymorphism’s effect size was estimated as moderate to strong, while its contribution to the PANSS psychopathology ranged from ~5.4–8.7%, with the lowest contribution observed for PANSS positive score changes and the highest for PANSS depressive factor changes. Our results indicated that ACE-I/D polymorphism had a statistically significant but weak gender-specific impact on psychopathology data and showed no association between ACE-I/D polymorphism and metabolic syndrome-related parameters. |
| Databáze: | OpenAIRE |
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