In situ clinical evaluation of a stabilised, stannous fluoride dentifrice

Autor: Nicola X West, P G Bellamy, Matthew L Barker, Andrew J. S. Mussett, Nicola Hellin, Robin Harris, Andrew Manly, Robert Francis Date
Rok vydání: 2014
Předmět:
Zdroj: Int Dent J
ISSN: 0020-6539
DOI: 10.1111/idj.12102
Popis: Objectives To compare the erosion protection efficacy of a stabilised, stannous fluoride (SnF2) dentifrice versus a sodium fluoride (NaF) dentifrice using a modified in situ clinical model. Methods This study, a randomised parallel group in situ design with in vivo product use and ex vivo acid challenge, compared: A, a dentifrice containing 1,450 ppm F as NaF; B, a dentifrice containing 1,450 ppm F (1,100 ppm F as SnF2 + 350 ppm F as NaF); and T, tap water. Sample size was n = 4 per group (total of 12 subjects) and within each subject appliances were placed on each side of the mouth (left and right). Enamel specimens were placed in different positions of the mouth (front, mid-front, mid-rear, rear) in each appliance (total = 8 specimens per subject). Product treatment was twice per day (lingual brushing for 30 seconds followed by swishing for 90 seconds with the resultant product/saliva slurry) in vivo for 15 days, and ex vivo acid treatment (0.02 m citric acid 5 minutes four times per day; total exposure time = 300 minutes). Data were analysed using a general linear repeated measures model with treatment, side and position as fixed effects. Within subjects, correlations were modelled assuming a different correlation and variance for treatment B relative to the other groups. Pairwise treatment differences were performed using a 5% two-sided significance level. Results Enamel loss (in μm) was significantly lower (P
Databáze: OpenAIRE
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