Restoring Bifidobacterium Infantis EVC001 to the Infant Gut Microbiome Significantly Reduces Intestinal Inflammation (OR12-01-19)
| Autor: | Giorgio Casaburi, Lindsey Contreras, Ryan D. Mitchell, Bethany M. Henrick, Mark A. Underwood, Steve Frese, Jennifer T. Smilowitz, Stephanie Chew |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Nutrition and Dietetics
Bifidobacterium longum biology Medicine (miscellaneous) Pathogenic bacteria biology.organism_classification medicine.disease medicine.disease_cause Immune system Immunology medicine Microbiome Breast feeding Dysbiosis Postpartum period Nutritional Immunology and Inflammation Food Science Bifidobacterium |
| Zdroj: | Current Developments in Nutrition. 3:nzz049.OR12-01 |
| ISSN: | 2475-2991 |
| Popis: | OBJECTIVES: Several seminal publications identify that Bifidobacterium longum subsp. infantis (B. infantis) has uniquely evolved to be the predominant strain in the breastfed infant gut; however, recent cohort studies indicate it is now far less abundant in infants born in industrialized nations, along with increased abundance of potentially pathogenic bacteria and gut dysbiosis. Importantly, recent clinical studies show enteric dysbiosis during the first 100 days of life can lead to higher risk of allergic and autoimmune-mediated disorders later in life. Given the importance of the microbiome for immune system development, we investigated the effect of B. infantis EVC001 consumption on intestinal inflammation in a cohort of healthy, term infants. METHODS: Forty (n = 40) infants were randomly selected from the previously conducted clinical study in which healthy, exclusively breastfed infants were either fed B. infantis EVC001 daily for 21 days, starting at day 7 postpartum, or received breastmilk alone. Stool samples were collected at multiple times postnatally and analyzed for cytokine production using a multiplex system and calprotectin ELISA. RESULTS: Baseline analysis indicated infants randomized to the EVC001 group produced naturally higher levels of IL2, IL5, IL6, IL10, TNFa and IFNg and lower levels of IL1b (all P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|