Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis
| Autor: | Hyogo Naoi, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Masato Karayama, Yuya Aono, Takuya Isayama, Hideki Yasui, K. Tanaka, Takafumi Suda, Yuzo Suzuki, Tomoyuki Fujisawa, Mineo Katsumata |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Exacerbation Idiopathic pulmonary fibrosis Gastroenterology S100A9 S100A8 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Calgranulin B Humans Calgranulin Calgranulin A In patient 030212 general & internal medicine Retrospective Studies biology business.industry Clinical course respiratory system Prognosis medicine.disease humanities respiratory tract diseases Acute exacerbation 030228 respiratory system Disease Progression biology.protein business Biomarkers |
| Zdroj: | Respiratory Investigation. 59:827-836 |
| ISSN: | 2212-5345 |
| Popis: | Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a devastating and life-threatening condition during its clinical course. Biomarkers for precisely anticipating the prognosis of AE-IPF remain to be fully established. The objective of this study was to clarify whether S100A8 and S100A9, which are calcium-binding proteins mainly produced by activated neutrophils, are significant prognostic biomarkers in AE-IPF.Methods: Thirty-seven patients with AE-IPF who were diagnosed and treated at our hospital were retrospectively evaluated. The serum levels of S100A8 and S100A9 were measured using enzyme-linked immunosorbent assay, and the relationships between these levels and clinical parameters or prognosis were evaluated.Results: The serum levels of S100A8 (median 386.5ng/mL) and S100A9 (median 60.2ng/mL) in patients with AE-IPF were significantly higher than those in age-matched healthy controls and in patients at IPF diagnosis (p |
| Databáze: | OpenAIRE |
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