[11C]-labeling of some caffeine derivatives for mapping adenosine A2a receptors by PET technique
| Autor: | I. Boros, Teréz Márián, Lajos Trón, Szabolcs Lehel, Géza Horváth, Zoltán Kovács, J. Szentmiklósi, Gábor Tóth |
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| Rok vydání: | 1999 |
| Předmět: |
Reaction conditions
chemistry.chemical_classification Stereochemistry Health Toxicology and Mutagenesis Iodide Public Health Environmental and Occupational Health Adenosine A2A receptor Orvostudományok Klinikai orvostudományok Pollution Combinatorial chemistry Adenosine receptor Analytical Chemistry Positron emission tomographic chemistry.chemical_compound Nuclear Energy and Engineering chemistry Radiology Nuclear Medicine and imaging Caffeine Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 242:309-312 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/bf02345557 |
| Popis: | [11C]-labeled form of ten A2a adenosine receptor specific 8-styryl-7-methyl-xanthine derivatives ([11C]-caffeines) were synthesised by N-methylation of the corresponding 8-styryl-xanthine derivatives using [11C]-methyl iodide in optimized reaction conditions. The results show that the [11C]-methylations take place with excellent radiochemical yields (35–93%), and can be utilised easily in online preparations. These labeled ligands may facilitate the positron emission tomographic (PET) investigation of adenosine A2a receptors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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