In vitro antitumor and immunotropic activity of carrageenans from red algae Chondrus armatus and their low‐molecular weight degradation products
| Autor: | Andrei Belousov, A. A. Kalitnik, Eduardas Cicinskas, Valeria V. Vikhareva, Valeria A. Mikhailova, Vladlena Tiasto, Maria A. Begun |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Cell Survival medicine.medical_treatment 0206 medical engineering Anti-Inflammatory Agents Biomedical Engineering Antineoplastic Agents 02 engineering and technology Red algae Carrageenan Polysaccharide Monocytes Biomaterials chemistry.chemical_compound Cell Line Tumor Neoplasms Chondrus medicine Humans Immunologic Factors Secretion Cells Cultured chemistry.chemical_classification biology Metals and Alloys Biological activity 021001 nanoscience & nanotechnology biology.organism_classification 020601 biomedical engineering In vitro Interleukin 10 Cytokine Biochemistry chemistry Ceramics and Composites Cytokines 0210 nano-technology |
| Zdroj: | Journal of Biomedical Materials Research Part A. 108:254-266 |
| ISSN: | 1552-4965 1549-3296 |
| DOI: | 10.1002/jbm.a.36812 |
| Popis: | Antitumor and immunotropic effects of κ-, λ-carrageenan from red marine algae Chondrus armatus and their low-molecular weight (LMW) degradation products were explored. Effects on human esophageal cancer cell lines KYSE30 and FLO1 viability and ability to induce production of pro- and anti-inflammatory cytokines by human monocytes was assessed. All polysaccharides demonstrated antimetabolic and cytostatic activity towards cancer lines, with high-molecular weight carrageenans possessing higher antimetabolic and lower cytostatic activity than their LMW degradation products. All carrageenans induced monocytes to produce pro-inflammatory cytokines IL1β, IL6, IL18, and TNFα. However, secretion of anti-inflammatory cytokine IL10 was induced only by LMW λ-carrageenan, which exhibited the highest cytokine production inducing efficacy overall. We demonstrate that LMW carrageenan degradation products not only retain biological activity of their precursors, but also increase their efficacy in type-dependent manner, allowing for their future development for pharmacological practice. |
| Databáze: | OpenAIRE |
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