Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country
| Autor: | Sahar Althawadi, Mohammed Shoukri, Bright Varghese, Abdulaziz Alsaif, Ali S. Alzahrani, Abdallah Alkhenizan, Alria Datijan, Abdulrahman A. Alrajhi, Grace Mary Fernandez, Sahal Al Hajoj |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Bacterial Diseases Medical Doctors Cross-sectional study Health Care Providers Interferon gamma release assay Nurses lcsh:Medicine Logistic regression Geographical locations 0302 clinical medicine Medicine and Health Sciences Public and Occupational Health 030212 general & internal medicine lcsh:Science Allied Health Care Professionals education.field_of_study Multidisciplinary Middle Aged Vaccination and Immunization Actinobacteria Vaccination Professions Infectious Diseases Female Research Article Adult medicine.medical_specialty Asia Tuberculosis Health Personnel Immunology Population Saudi Arabia Tuberculin Young Adult 03 medical and health sciences Tuberculosis diagnosis Physicians Internal medicine medicine Humans education Bacteria Tuberculin Test business.industry lcsh:R Organisms Biology and Life Sciences Tropical Diseases medicine.disease bacterial infections and mycoses Surgery Health Care Cross-Sectional Studies 030228 respiratory system People and Places Population Groupings lcsh:Q Preventive Medicine business Interferon-gamma Release Tests Mycobacterium Tuberculosis |
| Zdroj: | PLoS ONE, Vol 11, Iss 5, p e0154803 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Health care workers (HCW’s) are always at an increased risk of contracting tuberculosis (TB) infection. In Saudi Arabia, Interferon Gamma Release Assay (IGRA) has not been evaluated as a screening tool for latent TB infection (LTBI) among HCW’s considering their high demographic diversity. During February 2012 to January 2015 a cross sectional study has been conducted in a tertiary care center with maximum demographically diverse staff population in the capital city-Riyadh. After a short interview and consenting, all the candidates were subjected to tuberculin skin test (TST) and QuantiFERON TB gold In-tube test (QFT). A logistic regression analysis was carried out for establishing the associations between putative risk factors and the diagnostic tests. The candidates were classified according to geographical origin and a detailed analysis was conducted on the impact of their origin towards the results of TST and QFT. Of the 1595 candidates enrolled, 90.6% were BCG vaccinated, female (67.9%) and mainly nurses (53.2%). Candidates with high risk of suspected or confirmed TB patient exposure were 56.1% and 76.5% of them had |
| Databáze: | OpenAIRE |
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