Serum insulin-like growth factor-I, IGF binding protein-3 and IGFBP-3 protease activity after cranial irradiation

Autor:	A. J. Whatmore, Matthew S. Gill, Joanne Soden, Jeremy K.H. Wales, Louise Pennells, Stephen M Shalet, Peter E. Clayton, David Price, Vallo Tillmann
Rok vydání:	1998
Předmět:	Adult Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Proteolysis Growth hormone Growth hormone deficiency Central Nervous System Neoplasms Insulin-like growth factor Endocrinology Cranial Irradiation Internal medicine Endopeptidases medicine Humans Insulin-Like Growth Factor I Child Growth Disorders Protease Leukemia medicine.diagnostic_test Radiotherapy Chemistry Human Growth Hormone Growth factor medicine.disease Body Height Insulin-Like Growth Factor Binding Protein 3 Pediatrics Perinatology and Child Health Binding protein 3 Female hormones hormone substitutes and hormone antagonists
Zdroj:	Hormone research. 50(2)
ISSN:	0301-0163
Popis:	The relationship between peak growth hormone (GH), insulin-like growth factor I (IGF-I), IGF-I binding protein 3 (IGFBP-3) and IGFBP-3 protease activity was studied in 28 children and adolescents undergoing investigation of pituitary function 0.4–14.2 years after cranial or craniospinal irradiation for the treatment of CNS tumours distant from the hypothalamic-pituitary axis (n = 16) or prophylaxis against CNS leukaemia (n = 12). Seven out of 15 patients with GH deficiency (GHD) (defined as a peak GH concentration
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f9d1c450af537c6aaf0cc7a5372f5 https://pubmed.ncbi.nlm.nih.gov/9701699 Zobrazit plný text záznamu