Bilateral Testicular Metastases from Lung Adenocarcinoma Showing an Objective Response to Nivolumab: A Case Report and Review of the Literature
| Autor: | Daisuke Minami, Takuo Shibayama, Kenji Takada, Sachi Okawa, Hiroe Kayatani, Jun Nishimura, Keiichi Fujiwara, Taichi Ozeki, Atsushi Shimonishi, Ken Sato |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology endocrine system medicine.medical_specialty Lung Neoplasms Adenocarcinoma of Lung Case Report testicular metastasis Testicular metastasis 030204 cardiovascular system & hematology immune checkpoint inhibitors 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Testicular Neoplasms Internal medicine Internal Medicine medicine Humans Orchiectomy Lung cancer non-small cell lung cancer Aged nivolumab adenocarcinoma Lung business.industry Adrenal gland General Medicine medicine.disease medicine.anatomical_structure Adenocarcinoma 030211 gastroenterology & hepatology Nivolumab business Chemoradiotherapy |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.2927-19 |
| Popis: | A 69-year-old man who had undergone chemoradiotherapy for advanced pulmonary adenocarcinoma had bilateral testicular and adrenal gland masses on a routine follow-up examination. We performed left orchiectomy, and the histopathological examination confirmed metastatic pulmonary adenocarcinoma involving the extracted testis. He was treated for disease progression with nivolumab after unsuccessful cytotoxic chemotherapy, which resulted in regression of recurrent adrenal and right testicular tumors. We reviewed the existing literature on metastatic testicular tumors and found that testicular metastasis from lung cancer is rare and poses a chemotherapeutic challenge. Based on our experience, immune checkpoint inhibitors seem to have good efficacy for treating testicular metastasis. |
| Databáze: | OpenAIRE |
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