Programmed cell death proteins and chronic leukemia
| Autor: | Milica Strnad, Goran Brajušković, Snezana Cerovic, Stanka Romac |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Programmed cell death
caspase General Biochemistry Genetics and Molecular Biology antineoplastic agents medicine myeloid cell TP53 lcsh:QH301-705.5 Caspase B cell biology Cell growth B-Cell leukemia apoptosis medicine.disease Cell biology chronic mitochondria Leukemia medicine.anatomical_structure lcsh:Biology (General) Chronic leukemia UVB-induced apoptosis Apoptosis biology.protein Cancer research Bcl-2 protein family General Agricultural and Biological Sciences |
| Zdroj: | Archives of Biological Sciences, Vol 63, Iss 3, Pp 527-535 (2011) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Apoptosis or programmed cell death is a genetically regulated process of cellular suicide. Apoptosis has been implicated in a wide range of pathological conditions, and mutations in apoptotic genes play important roles in the process of malignant transformation. Chronic leukemia represents a neoplastic disorder caused primarily by defective programmed cell death, as opposed to increased cell proliferation. This paper presents the main results of our ten-year research on the apoptosis of leukemia cells. The research included the morphological aspects of the process, the effect of antineoplastic agents on the induction of apoptosis in leukemia cells and expression analysis of the proteins involved in programmed cell death. Special attention was paid to the expression and interaction of the Bcl-2 family of proteins in leukemia cells. The ultimate aim of the study of apoptosis of leukemic cells is the discovery of new biological agents that might be used in the treatment of chronic leukemia. |
| Databáze: | OpenAIRE |
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