Microtubule disruption and cognitive defects: effect of colchicine on learning behavior in rats
| Autor: | R. Chermat, G. Bensimon |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Clinical Biochemistry Amnesia Motor Activity Toxicology Biochemistry Microtubules Pathogenesis Behavioral Neuroscience chemistry.chemical_compound Cognition Microtubule Memory Neuroplasticity medicine Colchicine Animals Learning Biological Psychiatry Pharmacology Behavior Animal Dose-Response Relationship Drug Memoria Cognitive disorder Lumicolchicines Rats Inbred Strains medicine.disease Rats chemistry Toxicity Conditioning Operant medicine.symptom Psychology Neuroscience |
| Zdroj: | Pharmacology, biochemistry, and behavior. 38(1) |
| ISSN: | 0091-3057 |
| Popis: | Neuropathological findings in Alzheimer's disease (AD) suggest a possible involvement of microtubule dysfunction in neurodegenerative process pathogenesis. Because microtubules have a major role in neuronal plasticity, microtubule disruption could be also directly responsible for cognitive defects in AD. We report that in rats, continuous microtubule disruption induced by chronic colchicine administration results in a dose-dependent learning deficit. In addition, retention is also impaired. These cognitive defects are specific, as chronic colchicine induces no other behavioral toxicity within the study dose range. Colchicine-induced cognitive defects resemble those of AD, which are characterised by amnesia of recent learning and loss of formerly established memories. This new procedure of pharmacologically induced cognitive impairment may prove useful, both towards understanding AD pathogenesis and towards drug screening. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|