Recommended cognitive outcomes in preclinical Alzheimer's disease
Autor: | Joel H. Kramer, Bruce Albala, Michael T. Ropacki, Craig W. Ritchie, Karen Ritchie, Jeffrey Kaye, John Harrison, Christopher Randolph |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
Epidemiology Population MEDLINE Prodromal Symptoms Disease Neuropsychological Tests 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cognition Developmental Neuroscience Alzheimer Disease medicine Dementia Humans 030212 general & internal medicine education Psychiatry education.field_of_study Clinical Trials as Topic Health Policy Neuropsychology medicine.disease Psychiatry and Mental health Normative Biomarker (medicine) Neurology (clinical) Geriatrics and Gerontology Psychology 030217 neurology & neurosurgery |
Zdroj: | Ritchie, K, Ropacki, M, Albala, B, Harrison, J, Kaye, J, Kramer, J, Randolph, C & Ritchie, C W 2017, ' Recommended cognitive outcomes in preclinical Alzheimer's disease : Consensus statement from the European Prevention of Alzheimer's Dementia project ', Alzheimer's and Dementia, vol. 13, no. 2, pp. 186-195 . https://doi.org/10.1016/j.jalz.2016.07.154 |
ISSN: | 1552-5260 |
Popis: | The Horizon 2020/IMI European Prevention of Alzheimer's Dementia (EPAD) project will undertake large-scale proof-of-concept trials in predementia Alzheimer's disease (AD). Within EPAD, the monitoring of cognitive trajectories in the preclinical period will constitute a central outcome measure; however, there are currently no clear guidelines as to how this should be achieved as most measures have been developed for the period around dementia diagnosis. The EPAD Scientific Advisory Group for Clinical and Cognitive Outcomes identified appropriate cognitive measures based on a literature search covering both cognitive correlates of preclinical brain changes from imaging studies and cognitive changes observed over time in nondementia population cohorts developing incident dementia. These measures were evaluated according to the following criteria: validity, coherence with biomarker changes, psychometric properties, cross-cultural suitability, availability of alternative forms, and normative data limited practice effects. The resulting consensus statement provides recommendations for both future drug trials and research into preclinical Alzheimer's disease. |
Databáze: | OpenAIRE |
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