Current Status and Perspective Biomarkers in AFP Negative HCC: Towards Screening for and Diagnosing Hepatocellular Carcinoma at an Earlier Stage
| Autor: | Xinliang Ming, Ping Luo, Sanyun Wu, Xuelan Zuo, Yalan Yu, Shuo Li, Jiancheng Tu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Carcinoma Hepatocellular Pathology and Forensic Medicine 03 medical and health sciences High morbidity 0302 clinical medicine Serum biomarkers Internal medicine Biomarkers Tumor medicine Humans Stage (cooking) neoplasms business.industry Liver Neoplasms digestive oral and skin physiology Cancer General Medicine medicine.disease digestive system diseases Early Diagnosis 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma embryonic structures Biomarker (medicine) alpha-Fetoproteins business |
| Zdroj: | Pathology & Oncology Research. 26:599-603 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-019-00585-5 |
| Popis: | Hepatocellular carcinoma (HCC) is one of the most malignant cancer with high morbidity and mortality which lead to a serious burden to society. AFP (alpha-fetoprotein) is the most widely used serum biomarker to detect HCC worldwide. However, no AFP elevation have been found in many HCC and AFP analysis can't be used to screen HCC in these cases. Currently, many studies have been carried out to find reliable biomarker in diagnosing AFP-negative HCC. Such biomarker would help the diagnosis of AFP-negative HCC, ensuring the timely initiation of treatment. In this review, we highlight the important role of biomarkers that can differentiate AFP-negative HCCs, and discuss their potential clinical applications as biomarkers for the diagnosis of AFP-negative HCC. |
| Databáze: | OpenAIRE |
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