Dermatologic manifestations in pediatric patients after liver and HSCT: A 20‐year retrospective cohort study
| Autor: | Voranuch Chongsrisawat, Nataruks Chaijitraruch, Susheera Chatproedprai, Siriwan Wananukul, Darintr Sosothikul, Therdpong Tempark, Amatanun Tangthanapalakul, Piti Techavichit |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Impetigo Adolescent medicine.medical_treatment Mucocutaneous zone 030232 urology & nephrology chemical and pharmacologic phenomena Azathioprine 030230 surgery Skin Diseases Cohort Studies 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors immune system diseases hemic and lymphatic diseases Prevalence medicine Humans Child Retrospective Studies Transplantation business.industry Hematopoietic Stem Cell Transplantation Infant Leukemia cutis Retrospective cohort study Immunosuppression medicine.disease Dermatology Liver Transplantation surgical procedures operative Child Preschool Pediatrics Perinatology and Child Health Prednisolone Female medicine.symptom business medicine.drug |
| Zdroj: | Pediatric Transplantation. 25 |
| ISSN: | 1399-3046 1397-3142 |
| DOI: | 10.1111/petr.13916 |
| Popis: | LT and HSCT are now potentially curative treatments for many medical conditions. Dermatologic manifestations are one of the sequelae after transplantation. To study the prevalence and associated risk factors of dermatologic manifestations after pediatric LT and HSCT. A 20-year retrospective cohort study was conducted in children, aged ≤15 years, who received LT or HSCT from January 1, 1997, to December 31, 2017. Medical records were reviewed for data collection until December 31, 2018. A total of 70 LT and 51 HSCT recipients were included. The percentages of overall dermatologic manifestations after LT and HSCT were 64.3% and 64.7%, respectively. Viral infection was the most common manifestation in both groups, with mucocutaneous HSV infection as the most prevalent. One HSCT recipient developed leukemia cutis. GVHD was revealed in 27.5% of HSCT recipients. Impetigo and xerosis were significantly observed in patients using azathioprine and prednisolone. Approximately two-thirds of pediatric LT and HSCT recipients experienced dermatologic manifestations, potentially associated with immunosuppressive agents. Thus, regular skin examination and optimized immunosuppression would be beneficial in these recipients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|