Clinical Evaluation of Parenteral Cephalexin Sodium
| Autor: | Staffan Seeberg, Rune Svensson |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Adult
Male Microbiology (medical) Cefalotin medicine.medical_specialty Adolescent medicine.drug_class Sodium Cephalosporin Antibiotics Administration Oral chemistry.chemical_element Staphylococcal infections Injections Intramuscular Thrombophlebitis Sepsis polycyclic compounds Humans Medicine Infusions Parenteral Aged Cephalexin Clinical Trials as Topic General Immunology and Microbiology business.industry Osteomyelitis General Medicine Middle Aged Staphylococcal Infections medicine.disease Abscess Surgery Infectious Diseases chemistry Anesthesia Chronic Disease Injections Intravenous Wound Infection Female business Intramuscular injection medicine.drug |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 6:279-283 |
| ISSN: | 1651-1980 0036-5548 |
| Popis: | 22 patients with staphylococcal infections were treated with cephalexin sodium for parenteral use. The concentrations of cephalexin in serum following intravenous or intramuscular injections reached high levels, exceeding the required MIC values during 4–6 hours. Clinical improvement occurred in 95%. The causative agent was eradicated in 16/20 patients (80%). No haematological, hepatic or renal abnormalities attributable to cephalexin were seen during treatment or later. Mild thrombophlebitis was observed in 2 patients. During intramuscular treatment half of the patients complained of local pain, which could be avoided by dissolving cephalexin in lignocaine hydrochloride. |
| Databáze: | OpenAIRE |
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