Cerebral microdialysis and positron emission tomography after surgery for aneurysmal subarachnoid hemorrhage in grade I patients
| Autor: | Armand R. J. Girbes, Clemens M F Dirven, Dirk L. Knol, William P. Vandertop, David P. Noske, E.F.I. Comans, Saskia M. Peerdeman |
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| Přispěvatelé: | Neurosurgery, ANS - Amsterdam Neuroscience, Radiology and nuclear medicine, Epidemiology and Data Science, Intensive care medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Microdialysis Subarachnoid hemorrhage Ischemia Central nervous system disease Aneurysm Cerebral microdialysis Fluorodeoxyglucose F18 Reference Values medicine Humans cardiovascular diseases Aged Brain Chemistry medicine.diagnostic_test Vascular disease business.industry Intracranial Aneurysm Middle Aged Subarachnoid Hemorrhage medicine.disease Surgery Glucose Positron emission tomography Positron-Emission Tomography Anesthesia Female Neurology (clinical) Radiopharmaceuticals business |
| Zdroj: | Noske, D P, Peerdeman, S M, Comans, E F I, Dirven, C M F, Knol, D L, Girbes, A R J & Vandertop, W P 2005, ' Cerebral microdialysis and positron emission tomography after surgery for aneurysmal subarachnoid hemorrhage in grade I patients ', Surgical Neurology, vol. 64, no. 2, pp. 109-15; discussion 115 . https://doi.org/10.1016/j.surneu.2004.09.036 Surgical neurology, 64(2), 109-15; discussion 115. Elsevier BV Surgical Neurology, 64(2), 109-15; discussion 115. Elsevier BV |
| ISSN: | 0090-3019 |
| DOI: | 10.1016/j.surneu.2004.09.036 |
| Popis: | BACKGROUND: Using cerebral microdialysis, baseline values for energy-related chemical markers have been reported in awake patients. Radionuclide studies have demonstrated a locally decreased metabolism, thought to be the result of brain retraction. These baseline values, however, may not be applicable to patients after surgical aneurysm repair following a subarachnoid hemorrhage (SAH). We assessed metabolic chemical marker levels in World Federation of Neurological Surgeons Committee (WFNS) grade I SAH patients after aneurysm surgery and compared them with previously reported baseline values.METHODS: In 5 WFNS grade I SAH patients, energy-related chemical marker levels were obtained using microdialysis in the area of brain retraction after aneurysm surgery. In addition, an [(18)F]2-deoxy-d-glucose positron emission tomography (FDG-PET) was performed.RESULTS: The FDG-PET showed a decrease of glucose metabolism in the frontotemporal area. Comparing the mean values for chemical markers of this study with reported baseline values, the most striking difference was a mild decrease of pyruvate and an increase of the lactate/pyruvate ratio. In individual patients, some markers indicated possible ischemia. A consistent pattern or ischemic profile for all markers, however, was not found.CONCLUSION: FDG-PET scanning confirmed postoperative metabolic changes found in previous studies. Mean interstitial chemical marker levels ranged from normal to mildly deviant compared with reference chemical marker levels for awake patients and are likely to be applicable in SAH patients after aneurysm repair. |
| Databáze: | OpenAIRE |
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