Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency
| Autor: | Bae Hoon Lee, Gaia Ferracci, Mengxiang Zhu, Yingying Wang, Nam-Joon Cho, Jing Zheng |
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| Přispěvatelé: | School of Materials Science & Engineering |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Materials science food.ingredient Biomaterials-proteins Biomaterials - proteins Cell Survival lcsh:Medicine Biocompatible Materials Materials testing Gelatin Article Cell Line Biomaterials 03 medical and health sciences 0302 clinical medicine food Materials Testing Humans lcsh:Science Mechanical Phenomena Multidisciplinary lcsh:R Hydrogels Controllability Engineering::Materials [DRNTU] 030104 developmental biology Freeze Drying Chemical engineering Self-healing hydrogels Surface modification lcsh:Q 030217 neurology & neurosurgery Enzymatic degradation |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) |
| Popis: | Gelatin methacryloyl (GelMA) is a versatile material for a wide range of bioapplications. There is an intense interest in developing effective chemical strategies to prepare GelMA with a high degree of batch-to-batch consistency and controllability in terms of methacryloyl functionalization and physiochemical properties. Herein, we systematically investigated the batch-to-batch reproducibility and controllability of producing GelMA (target highly and lowly substituted versions) via a one-pot strategy. To assess the GelMA product, several parameters were evaluated, including the degree of methacryloylation, secondary structure, and enzymatic degradation, along with the mechanical properties and cell viability of GelMA hydrogels. The results showed that two types of target GelMA with five batches exhibited a high degree of controllability and reproducibility in compositional, structural, and functional properties owing to the highly controllable one-pot strategy. |
| Databáze: | OpenAIRE |
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