TIMP-1: a marker of left ventricular diastolic dysfunction and fibrosis in hypertension
| Autor: | M Mitchell Lindsay, Paul R. Maxwell, Francis G. Dunn |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Diastole Blood Pressure Collagen Type I Muscle hypertrophy Pathogenesis Cohort Studies Electrocardiography N-terminal telopeptide Fibrosis Predictive Value of Tests Internal medicine Renin Internal Medicine medicine Humans Aldosterone Tissue Inhibitor of Metalloproteinase-1 business.industry Middle Aged medicine.disease Peptide Fragments Echocardiography Hypertension Cardiology Myocardial fibrosis Female Hypertrophy Left Ventricular Collagen Isovolumic relaxation time business Peptides Procollagen |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 40(2) |
| ISSN: | 1524-4563 |
| Popis: | This study was designed to document noninvasively the pathological mechanisms responsible for myocardial fibrosis and to assess the clinical utility of plasma markers of collagen synthesis and degradation as screening tools for the assessment of fibrosis in hypertension. We studied 100 never-treated hypertensive patients and 50 normal subjects. Echocardiographic assessment was made of left ventricular (LV) mass and diastolic filling using measurement of E:A ratio, E wave deceleration time (E dec), and isovolumic relaxation time (IVRT). The presence of diastolic dysfunction was taken as a surrogate marker for the presence of myocardial fibrosis. Plasma carboxy-terminal propeptide of collagen type I (PICP), carboxy-terminal telopeptide of collagen type I (CITP), and tissue inhibitor of matrix metalloproteinases type I (TIMP-1) were measured as markers of collagen synthesis, degradation, and inhibition of degradation, respectively. Plasma TIMP-1 was significantly elevated in the hypertensive cohort (358 ng/mL versus 253 ng/mL, P P P P r =0.26, P r =0.41, P 500 ng/mL had a specificity of 97% and a positive predictive value of 96% in predicting diastolic dysfunction. In patients with untreated hypertension, there is evidence of increased collagen synthesis, degradation, and inhibition of degradation resulting in fibrosis. Our results demonstrate that plasma TIMP-1 correlates with markers of LV diastolic filling, is predictive of LV dysfunction, and is a potential noninvasive marker of fibrosis. |
| Databáze: | OpenAIRE |
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