Ontogeny of surfactant proteins A and B in human amniotic fluid as indices of fetal lung maturity
| Autor: | Gloria S. Pryhuber, Michael J. McMahan, Iris Fink, William M. Hull, Jeffrey A. Whitsett |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.medical_specialty Amniotic fluid Pulmonary Surfactant-Associated Proteins Proteolipids Prenatal diagnosis Enzyme-Linked Immunosorbent Assay Gestational Age Fetal Organ Maturity Pregnancy Internal medicine Prenatal Diagnosis medicine Rupture of membranes Humans Lung Fetus Respiratory Distress Syndrome Newborn Pulmonary Surfactant-Associated Protein A business.industry Infant Newborn Gestational age Pulmonary Surfactants medicine.disease Amniotic Fluid Endocrinology Pediatrics Perinatology and Child Health Gestation Apgar score Female business |
| Zdroj: | Pediatric research. 30(6) |
| ISSN: | 0031-3998 |
| Popis: | Surfactant proteins A and B (SP-A and SP-B) were measured in human amniotic fluid by ELISA and correlated with lecithin to sphingomyelin ratio (L/S), phosphatidylglycerol (PG), and perinatal outcome. Amniotic fluid SP-A, SP-B, and L/S increased with advancing gestation. SP-A was detected at 19 wk gestation and increased dramatically in the 3rd trimester of pregnancy. SP-B was first detectable at 31 wk gestation and increased significantly to term. SP-A was a more specific predictor of nonrespiratory distress syndrome (RDS) than L/S or SP-B; however, the sensitivity of SP-A in predicting RDS was less than L/S less than 2.0 (26.3 versus 82.3%, respectively). In 209 pregnancies assessed within 48 h of delivery, the sensitivity of SP-B in predicting RDS (nondetectable SP-B) was comparable to the L/S, however, SP-B = 0 was frequently observed in mature infants, limiting its specificity for prediction of RDS. The greatest sensitivity and specificity were achieved with the measurement of L/S less than 2.0 and negative PG, which correctly predicted 100% of the infants with RDS and 94% of those who did not develop the disorder. Measurement of SP-A or SP-B did not improve the prediction of RDS. SP-A, SP-B, and L/S were not affected by infant sex, Apgar score, rupture of membranes, size for gestational age, maternal diabetes, hypertension, or exposure to medications. SP-A, SP-B, and L/S were significantly elevated in amniotic fluid from black mothers. SP-A was significantly elevated in amniotic fluid from mothers who smoked during pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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