Diastolic left ventricular dysfunction in ankylosing spondylitis-A systematic review and meta-analysis
| Autor: | Carlo J. Van Dongen, Mike J L Peters, Michael T. Nurmohamed, Yvo M. Smulders, T.C. Konings, S.C. Heslinga, Irene E. van der Horst-Bruinsma |
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| Přispěvatelé: | Cardiology, Internal medicine, Rheumatology, ICaR - Circulation and metabolism |
| Rok vydání: | 2014 |
| Předmět: |
Ankylosing spondylitis
medicine.medical_specialty business.industry Diastole Disease medicine.disease Control subjects Prognosis Ventricular Dysfunction Left Anesthesiology and Pain Medicine Rheumatology Heart failure Meta-analysis Internal medicine medicine Cardiology Humans Clinical significance Spondylitis Ankylosing business Isovolumetric contraction |
| Zdroj: | Heslinga, S C, Van Dongen, C J, Konings, T C, Peters, M J, van der Horst-Bruinsma, I E, Smulders, Y M & Nurmohamed, M T 2014, ' Diastolic left ventricular dysfunction in ankylosing spondylitis-A systematic review and meta-analysis ', Seminars in Arthritis and Rheumatism, vol. 44, no. 1, pp. 14-19 . https://doi.org/10.1016/j.semarthrit.2014.02.004 Seminars in Arthritis and Rheumatism, 44(1), 14-19. W.B. Saunders Ltd |
| ISSN: | 0049-0172 |
| Popis: | Objectives Ankylosing spondylitis (AS) is associated with increased mortality largely due to cardiovascular disease. Diastolic left ventricular (LV) dysfunction serves as a precursor to chronic heart failure and may cause morbidity and mortality. A systematic literature search was conducted to determine the prevalence of diastolic LV dysfunction in patients with AS. Methods We identified all echocardiographic studies investigating diastolic LV function in patients with AS. The initial search yielded 166 studies of which 11 met the inclusion criteria. Results Compared to control subjects, AS patients had a worse E/A ratio [mean difference −0.13m/s (95% CI: −0.19 to −0.07)], a prolonged deceleration time [mean difference 13.90ms (95% CI: 6.03–21.78)], and a prolonged mean isovolumetric relaxation time [mean difference 8.06ms (95% CI: 3.23–12.89)], all suggestive of diastolic LV dysfunction. The best way to establish diastolic LV dysfunction, however, is to combine E/A ratio, deceleration time, and isovolumetric relaxation time. The latter has been done in 3 studies, all reaffirming an increased prevalence rate of diastolic LV dysfunction in AS patients as compared with control subjects, i.e., 9% versus 0%, 30% versus 12%, and 45% versus 18%, respectively. Conclusions Our observations support the current evidence base for an increased risk of diastolic LV dysfunction in AS. However, larger studies are needed to investigate the exact magnitude of diastolic LV dysfunction and its clinical relevance in patients with AS. |
| Databáze: | OpenAIRE |
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