Novel alpha-2-macroglobulin cleaved fragments as biomarkers of early liver fibrosis in patients with chronic hepatitis C
| Autor: | M. Lapalus, Sonia Hem, Isabelle Batxelli-Molina, Daniel Laune, Bénédicte Jardin-Watelet, Sophie Calvayrac-Pawlowski, Tarik Asselah, Véronique Moulin |
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| Přispěvatelé: | Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche Protéomique (PROTEOMIQUE), Institut National de la Recherche Agronomique (INRA), Bio-Rad laboratories, Inc. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Gene isoform
40 kDa isoforms Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Liver fibrosis medicine.disease Fold change 3. Good health Chronic hepatitis Fibrosis Virology Liver biopsy 2 macroglobulin [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology medicine chronic hepatitis C In patient Hepatic fibrosis business serum early diagnosis liver fibrosis |
| Zdroj: | Future Virology Future Virology, Future Medicine, 2015, 10 (1), pp.5-16. ⟨10.2217/fvl.14.98⟩ |
| ISSN: | 1746-0794 1746-0808 |
| DOI: | 10.2217/fvl.14.98⟩ |
| Popis: | ABSTRACT Aim: Liver biopsy is considered the gold standard for the diagnosis and staging of hepatic fibrosis in patients with chronic hepatitis C and is now progressively replaced by noninvasive procedures. We aimed at improving α-2-macroglobulin diagnostic value for liver fibrosis by identifying new isoforms that may be specifically related to early stages of the pathology. Materials & methods: α-2-Macroglobulin isoforms were characterized in serum samples from patients with chronic hepatitis C and mild (F1) to moderate (F2) fibrosis by proteomic methods. Results: New biological 40 kDa C-terminal α-2-macroglobulin fragments were identified as potential biomarkers of early fibrosis (fold change = 1.55; p < 0.01). Conclusion: The serum concentration of α-2-macroglobulin fragments allows a better differentiation of F1 and F2 fibrosis stages than total α-2-macroglobulin isoforms. |
| Databáze: | OpenAIRE |
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