Carcinoembryonic antigen, its spatial structure and localization of antigenic determinants
| Autor: | A. F. Pavlenko, Yu. S. Ovodov, L. V. Mikhalyuk, V. P. Glasunov, A. V. Kurika, I. V. Chikalovets |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Circular dichroism
Glycosylation biology Protein Conformation Circular Dichroism Carbohydrates Tryptophan Neuraminidase General Medicine Epitope Carcinoembryonic Antigen chemistry.chemical_compound Epitopes Protein structure Carcinoembryonic antigen Biochemistry Antigen chemistry biology.protein Carbohydrate Conformation Histidine Spectrophotometry Ultraviolet Carbohydrate conformation |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 11(6) |
| ISSN: | 1010-4283 |
| Popis: | The effects of temperature and pH on the spatial structure of carcinoembryonic antigen (CEA) and its various derivatives are studied by circular dichroic spectroscopy and differential UV spectroscopy. The spatial organization of the protein portion of CEA and its derivatives as revealed by spectroscopic evidence is discussed with respect to the antigenic activity of the species studied. We conclude that the protein portion of CEA consists mainly of a beta-structural type. Using the various modifications of the sugar moiety and the protein portion, antigenic determinants of CEA are shown to possess the main conformational character of the molecule while participation of the sugars in the formation and orientation of the carbohydrate chains relative to the protein core of the antigen appear to be important. |
| Databáze: | OpenAIRE |
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