Genetic of the ABO blood system and its link with the immune system

Autor: Luiz Carlos de Mattos, Haroldo Wilson Moreira
Přispěvatelé: Faculty of Medicine of São José do Rio Preto Molecular Biology Department, Universidade Estadual Paulista (Unesp)
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Zdroj: SciELO
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Revista Brasileira de Hematologia e Hemoterapia v.26 n.1 2004
Revista brasileira de hematologia e hemoterapia
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)
instacron:ABHHTC
Revista Brasileira de Hematologia e Hemoterapia, Volume: 26, Issue: 1, Pages: 60-63, Published: MAR 2004
ISSN: 1516-8484
Popis: Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:40:36Z No. of bitstreams: 1 S1516-84842004000100012.pdf: 126403 bytes, checksum: c812e2e1e21413f93a129cdb5d885750 (MD5) Made available in DSpace on 2013-08-22T18:40:36Z (GMT). No. of bitstreams: 1 S1516-84842004000100012.pdf: 126403 bytes, checksum: c812e2e1e21413f93a129cdb5d885750 (MD5) Previous issue date: 2004-03-01 Made available in DSpace on 2013-09-30T19:26:25Z (GMT). No. of bitstreams: 2 S1516-84842004000100012.pdf: 126403 bytes, checksum: c812e2e1e21413f93a129cdb5d885750 (MD5) S1516-84842004000100012.pdf.txt: 17624 bytes, checksum: 85777e37334c55db310276c4ab8f677f (MD5) Previous issue date: 2004-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:07:24Z No. of bitstreams: 2 S1516-84842004000100012.pdf: 126403 bytes, checksum: c812e2e1e21413f93a129cdb5d885750 (MD5) S1516-84842004000100012.pdf.txt: 17624 bytes, checksum: 85777e37334c55db310276c4ab8f677f (MD5) Made available in DSpace on 2014-05-20T15:07:25Z (GMT). No. of bitstreams: 2 S1516-84842004000100012.pdf: 126403 bytes, checksum: c812e2e1e21413f93a129cdb5d885750 (MD5) S1516-84842004000100012.pdf.txt: 17624 bytes, checksum: 85777e37334c55db310276c4ab8f677f (MD5) Previous issue date: 2004-03-01 Peter J. D'Adamo, autor do livro Eat Right For Your Type, escreve que o grupo O representa o primeiro tipo sangüíneo que surgiu nos humanos e também afirma que os grupos sangüíneos constituem as bases do sistema imune. Recentes estudos filogenéticos realizados em primatas humanos e não humanos estabeleceram que o gene A representa a forma ancestral dos genes que ocupam o locus ABO. Associações entre os grupos sangüíneos ABO, doenças infecciosas, não infecciosas e imunodeficiências também foram relatadas. Diante das proposições do autor, as quais se opõem às informações resultantes de recentes estudos moleculares e filogenéticos, nossa intenção é apresentar algumas reflexões sobre a genética e a evolução dos genes do sistema ABO e as conexões deste sistema com o sistema imune. In the book Eat Right For Your Type the author Peter J. D'Adamo writes that the O blood type was the first blood type to appear in humans and affirms that the blood groups are the key to the immune system. Some recent phylogenetic network studies in humans and non-human primates implies that the A gene represents an ancient form of the ABO genes. Relationships between blood groups and infectious and noninfectious diseases and immunodeficiency abnormalities have also been reported in the literature. As D'Adamo's propositions seem to be in opposition with the current knowledge, we present in this paper some comments about the genetics and the evolution of the ABO blood group genes and some links between this blood system and the functioning of the immune system. Faculty of Medicine of São José do Rio Preto Molecular Biology Department UNESP Faculty of Pharmaceutical Sciences Clinical Analysis Department UNESP Faculty of Pharmaceutical Sciences Clinical Analysis Department
Databáze: OpenAIRE
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