Adhesive Catechol-Conjugated Hyaluronic Acid for Biomedical Applications: A Mini Review
| Autor: | Ji Hyun Ryu, Chaemyeong Lee, Jongho Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
adhesive
Biocompatibility Nanotechnology 02 engineering and technology Conjugated system 010402 general chemistry lcsh:Technology 01 natural sciences lcsh:Chemistry chemistry.chemical_compound Tissue engineering hyaluronic acid Hyaluronic acid General Materials Science bio-inspired lcsh:QH301-705.5 Instrumentation Fluid Flow and Transfer Processes chemistry.chemical_classification Tissue Adhesion lcsh:T organic chemicals Process Chemistry and Technology General Engineering Polymer catechol 021001 nanoscience & nanotechnology lcsh:QC1-999 0104 chemical sciences Computer Science Applications lcsh:Biology (General) lcsh:QD1-999 chemistry lcsh:TA1-2040 Drug delivery bacteria Adhesive dopamine lcsh:Engineering (General). Civil engineering (General) 0210 nano-technology lcsh:Physics |
| Zdroj: | Applied Sciences, Vol 11, Iss 21, p 21 (2021) |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app11010021 |
| Popis: | Recently, catechol-containing polymers have been extensively developed as promising materials for surgical tissue adhesives, wound dressing, drug delivery depots, and tissue engineering scaffolds. Catechol conjugation to the polymer backbone provides adhesive properties to the tissue and does not significantly affect the intrinsic properties of the polymers. An example of a catecholic polymer is catechol-conjugated hyaluronic acid. In general, hyaluronic acid shows excellent biocompatibility and biodegradability; thus, it is used in various medical applications. However, hyaluronic acid alone has poor mechanical and tissue adhesion properties. Catechol modification considerably increases the mechanical and underwater adhesive properties of hyaluronic acid, while maintaining its biocompatibility and biodegradability and enabling its use in several biomedical applications. In this review, we briefly describe the synthesis and characteristics of catechol-modified hyaluronic acid, with a specific focus on catechol-involving reactions. Finally, we discuss the basic concepts and therapeutic effects of catechol-conjugated hyaluronic acid for biomedical applications. |
| Databáze: | OpenAIRE |
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