Hydroxyhydroquinone impairs fat utilization in mice by reducing nitric oxide availability
| Autor: | Koichi Misawa, Ishida Keiko, Akira Shimotoyodome, Masaki Yamamoto |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
0301 basic medicine medicine.medical_specialty Physiology Palmitic Acid Nitric oxide Mice 03 medical and health sciences chemistry.chemical_compound Oxygen Consumption Chlorogenic acid Internal medicine medicine Animals Hydrogen peroxide Hydroxyhydroquinone Beta oxidation chemistry.chemical_classification Original Paper Catabolism Fatty acid Calorimetry Indirect Lipid metabolism Hydrogen Peroxide Lipid Metabolism Hydroquinones Bioavailability 030104 developmental biology Endocrinology Adipose Tissue Liver chemistry Hepatocytes Fat metabolism Oxidation-Reduction |
| Zdroj: | The Journal of Physiological Sciences |
| ISSN: | 1880-6562 1880-6546 |
| Popis: | Habitual consumption of chlorogenic acid compounds (CGAs) from coffee increases fat catabolism and reduces body fat; however, the contribution of roasted coffee remains unclear. Hydroxyhydroquinone (HHQ) impairs the vasodilatory and antihypertensive effects of CGAs by reducing nitric oxide (NO) bioavailability. Since HHQ also reduces fat catabolism, we hypothesized that HHQ does so by decreasing NO availability. Therefore, we investigated the effect of HHQ on energy metabolism in KKAy mice. In HHQ-treated mice, fat oxidation was significantly low and dose-dependent, serum and urinary hydrogen peroxide were high, and plasma NO metabolites and S-nitrosylated liver proteins were low. In HHQ-treated mouse hepatocytes, the palmitate-induced increase in cellular oxygen consumption was negatively affected, and HHQ or L-NAME reduced cellular fatty acid utilization. In conclusion, HHQ can impair fat utilization by reducing NO availability in mice. Protein S-nitrosylation reduction in liver cells after HHQ consumption may be associated with impaired fatty acid oxidation. Electronic supplementary material The online version of this article (10.1007/s12576-018-0605-9) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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