Triticum aestivum sprout extract attenuates 2,4‑dinitrochlorobenzene‑induced atopic dermatitis‑like skin lesions in mice and the expression of chemokines in human keratinocytes
| Autor: | Dae‑Ki Kim, Young-Mi Lee, Ji-Hyun Lee, Hyeon‑Hui Ki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Keratinocytes Cancer Research Chemokine medicine.medical_treatment Immunoglobulin E Biochemistry 2 4-Dinitrochlorobenzene Dermatitis Atopic 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Interferon Genetics medicine Dinitrochlorobenzene Animals Humans Molecular Biology Cells Cultured Triticum biology business.industry Plant Extracts Tumor Necrosis Factor-alpha Atopic dermatitis medicine.disease HaCaT Disease Models Animal 030104 developmental biology Cytokine STAT1 Transcription Factor Oncology chemistry Gene Expression Regulation Seedlings 030220 oncology & carcinogenesis Immunology biology.protein Molecular Medicine Cytokines Tumor necrosis factor alpha Female Chemokines business medicine.drug |
| Zdroj: | Molecular medicine reports. 18(3) |
| ISSN: | 1791-3004 |
| Popis: | Atopic dermatitis (AD) is a common chronic, recurring, inflammatory skin disease. A number of researchers have been seeking safe AD therapies for a long time. Triticum aestivum sprouts (TAEE), known as wheatgrass, are one of the most widely used health foods worldwide. They show numerous beneficial effects, including anticancer, anti‑inflammatory, anti‑oxidant, anti‑obesity, anti‑colitis and anti‑allergy effects; however, their effect on AD is unknown. In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells). Oral administration of 200 mg/kg TAEE for 10 days significantly decreased the skin thickness, transepidermal water loss and serum immunoglobulin E levels in DNCB‑treated mice. In addition, TAEE reduced the secretion of inflammatory chemokines via regulation of the signal transducer and activator of transcription 1 and suppressor of cytokine signaling pathways in TNF‑α‑ and IFN‑γ‑stimulated HaCaT cells. These results indicate that TAEE may have beneficial effects in the treatment and prevention of AD and associated skin diseases. |
| Databáze: | OpenAIRE |
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