Evaluation of Different Antiretroviral Drug Protocols on Naturally Infected Feline Immunodeficiency Virus (FIV) Cats in the late Phase of the Asymptomatic Stage of Infection
| Autor: | Adriana Patricia Suraniti, Adriana Fontanals, Paola B. Pisano, N.V. Gómez, Graciela Mira, María Amelia Gisbert, Víctor Castillo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Feline immunodeficiency virus Anti-HIV Agents antiretroviral therapy CD4-CD8 Ratio lcsh:QR1-502 Alpha interferon Biology Cat Diseases Asymptomatic FIV retrovirus visual and auditory evoked potentials ZDV 3TC valproic acid rHuIFN-α Article lcsh:Microbiology Zidovudine immune system diseases Antiretroviral Therapy Highly Active Feline Acquired Immunodeficiency Syndrome Virology medicine Animals CATS Interferon-alpha Lamivudine virus diseases Viral Load biology.organism_classification Treatment Outcome Infectious Diseases Immunology Cats Evoked Potentials Auditory Evoked Potentials Visual Female medicine.symptom Viral load medicine.drug |
| Zdroj: | Viruses; Volume 4; Issue 6; Pages: 924-939 Viruses, Vol 4, Iss 6, Pp 924-939 (2012) Viruses |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v4060924 |
| Popis: | The aim of this study was to evaluate the efficacy of the antiretrovirals: Zidovudine (ZDV) alone; ZDV + Recombinant Human Interferon-α (rHuIFN-α); ZDV + Lamivudine (3TC) and ZDV + valproic acid (Valp) on naturally feline immunodeficiency virus (FIV)-infected cats, in the late phase of the asymptomatic stage of infection. The follow-up was performed over one year, through clinical evaluation and the determination of viral loads and CD4+/CD8+ ratios. Neurological signs were studied by visual and auditory evoked potentials (VEP, AEP) and the responses were abnormal in 80% of the FIV-infected cats. After one year, an improvement in VEP and AEP was observed in the ZDV + Valp group and a worsening in the group receiving ZDV + rHuIFN-α. The CD4+/CD8+ ratio showed a significant increase (both intra and inter-groups) only in ZDV and ZDV + 3TC, between their pre-treatment and one year values, as well as among the other groups. Viral load only showed a significant decrease in ZDV and ZDV + 3TC groups, when comparing the values at one year of treatment vs. pre-treatment values and when the different groups were compared. In addition, the viral load decrease was significantly more pronounced in the ZDV + 3TC vs. ZDV group. We conclude that ZDV and ZDV + 3TC produce significant reductions in viral load and stimulate a recovery of the CD4+/CD8+ ratio, compared with the other protocols. It is clear that the addition of 3TC resulted in a greater reduction in viral load than use of ZDV as a single drug. Therefore, the combination ZDV + 3TC could be more effective than the sole use of ZDV. |
| Databáze: | OpenAIRE |
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