Gastric Emptying-Limited Oral Absorption of .ALPHA.-Linolenic Acid Administered as a Milk Fat-Globule Membrane (MFGM) Emulsion in Rats
| Autor: | Shoji Ozeki, Jun Watanabe, Michie Sekiya, Hiroaki Yuasa |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Cell Membrane Permeability Pharmaceutical Science Absorption (skin) Gastroenterology Intestinal absorption Dosage form Fats Oral administration Internal medicine Intestine Small medicine Animals Rats Wistar Pharmacology Chromatography Gastric emptying Chemistry Stomach Inulin alpha-Linolenic Acid General Medicine Small intestine Rats Milk medicine.anatomical_structure Gastric Emptying Intestinal Absorption Emulsion Emulsions |
| Zdroj: | Biological and Pharmaceutical Bulletin. 17:1262-1266 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.17.1262 |
| Popis: | As a study to assess the potential application of milk fat-globule membrane (MFGM), which is of natural origin and expected to be a safer alternative to synthetic emulsifiers, to pharmaceutical dosage forms, the oral absorption of alpha-linolenic acid was evaluated by the analysis of gastrointestinal disposition after oral administration as an MFGM emulsion to rats. A linear model incorporated with first-order gastric emptying followed by first-order intestinal absorption was fitted to the data of the remaining fraction of alpha-linolenic acid versus time profiles for the stomach and small intestine to estimate the rate constants of gastric emptying (kg) and intestinal absorption (ka). The ka (0.045 min-1) was about 4 times larger than the kg (0.011 min-1). The kg was comparable to the apparent oral absorption rate constant estimated by the pharmacokinetic analysis of plasma concentration data. These results suggest that the oral absorption of alpha-linolenic acid administered as MFGM emulsion is gastric emptying-limited and, hence, any change in the intestinal absorption process would only modestly affect its oral absorption. |
| Databáze: | OpenAIRE |
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