| Autor: |
Le Peng, Gaoxiang Luo, Andrew Walker, Zachary Zaiman, Emma K Jones, Hemant Gupta, Kristopher Kersten, John L Burns, Christopher A Harle, Tanja Magoc, Benjamin Shickel, Scott D Steenburg, Tyler Loftus, Genevieve B Melton, Judy Wawira Gichoya, Ju Sun, Christopher J Tignanelli |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of the American Medical Informatics Association : JAMIA. 30(1) |
| ISSN: |
1527-974X |
| Popis: |
Objective Federated learning (FL) allows multiple distributed data holders to collaboratively learn a shared model without data sharing. However, individual health system data are heterogeneous. “Personalized” FL variations have been developed to counter data heterogeneity, but few have been evaluated using real-world healthcare data. The purpose of this study is to investigate the performance of a single-site versus a 3-client federated model using a previously described Coronavirus Disease 19 (COVID-19) diagnostic model. Additionally, to investigate the effect of system heterogeneity, we evaluate the performance of 4 FL variations. Materials and methods We leverage a FL healthcare collaborative including data from 5 international healthcare systems (US and Europe) encompassing 42 hospitals. We implemented a COVID-19 computer vision diagnosis system using the Federated Averaging (FedAvg) algorithm implemented on Clara Train SDK 4.0. To study the effect of data heterogeneity, training data was pooled from 3 systems locally and federation was simulated. We compared a centralized/pooled model, versus FedAvg, and 3 personalized FL variations (FedProx, FedBN, and FedAMP). Results We observed comparable model performance with respect to internal validation (local model: AUROC 0.94 vs FedAvg: 0.95, P = .5) and improved model generalizability with the FedAvg model (P Conclusion FedAvg can significantly improve the generalization of the model compared to other personalization FL algorithms; however, at the cost of poor internal validity. Personalized FL may offer an opportunity to develop both internal and externally validated algorithms. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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