OMICs approaches in diarrhetic shellfish toxins research
| Autor: | Pedro Reis Costa, Marisa Freitas, André M. Almeida, Dany Domínguez-Pérez, Vitor Vasconcelos, José Carlos Martins, Hugo Osório, Alexandre Campos |
|---|---|
| Přispěvatelé: | Instituto de Investigação e Inovação em Saúde, Repositório Científico do Instituto Politécnico do Porto |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Proteomics
Food Safety mechanisms of toxicity Health Toxicology and Mutagenesis lcsh:Medicine Review 010501 environmental sciences Toxicology 01 natural sciences Shellfish Poisoning / metabolism transcriptomics Aquaculture aquatic contamination Biotransformation Trophic level 0303 health sciences biology risk assessment Genomics metabolomics Shellfish poisoning Zoology Marine Toxins / toxicity 03 medical and health sciences proteomics medicine Animals Humans Shellfish Poisoning 14. Life underwater 030304 developmental biology 0105 earth and related environmental sciences Shellfish diarrhetic shellfish toxins business.industry lcsh:R Dinoflagellate Shellfish Poisoning / etiology Food safety biology.organism_classification medicine.disease Omics Diarrhetic sellfish toxins 13. Climate action Marine Toxins business Marine toxin Biomarkers Mechanims of toxicity |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP Toxins Toxins, Vol 12, Iss 493, p 493 (2020) |
| Popis: | Diarrhetic shellfish toxins (DSTs) are among the most prevalent marine toxins in Europe’s and in other temperate coastal regions. These toxins are produced by several dinoflagellate species; however, the contamination of the marine trophic chain is often attributed to species of the genus Dinophysis. This group of toxins, constituted by okadaic acid (OA) and analogous molecules (dinophysistoxins, DTXs), are highly harmful to humans, causing severe poisoning symptoms caused by the ingestion of contaminated seafood. Knowledge on the mode of action and toxicology of OA and the chemical characterization and accumulation of DSTs in seafood species (bivalves, gastropods and crustaceans) has significantly contributed to understand the impacts of these toxins in humans. Considerable information is however missing, particularly at the molecular and metabolic levels involving toxin uptake, distribution, compartmentalization and biotransformation and the interaction of DSTs with aquatic organisms. Recent contributions to the knowledge of DSTs arise from transcriptomics and proteomics research. Indeed, OMICs constitute a research field dedicated to the systematic analysis on the organisms’ metabolisms. The methodologies used in OMICs are also highly effective to identify critical metabolic pathways affecting the physiology of the organisms. In this review, we analyze the main contributions provided so far by OMICs to DSTs research and discuss the prospects of OMICs with regard to the DSTs toxicology and the significance of these toxins to public health, food safety and aquaculture. This work was funded by Portuguese Science Foundation (Fundação para a Ciência e a Tecnologia, FCT) and under the Projects MOREBIVALVES (PTDC/ASP-PES/31762/2017) and UID/Multi/04423/2013 co-financed by NORTE 2020, Portugal 2020 and the European Union through the ERDF, and by FCT. AM Almeida acknowledges funding from unit program LEAF–Linking Landscape, Environment, Agriculture and Food Research Centre (ISA–University of Lisbon) funded by the FCT Strategic Project (UID/AGR/04129/2019). This work had support from the Portuguese Mass Spectrometry Network, integrated in the National Roadmap of Research Infrastructures of Strategic Relevance (ROTEIRO/0028/2013; LISBOA-01-0145-FEDER-022125). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|